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    Rhoa ras homolog family member A [ Mus musculus (house mouse) ]

    Gene ID: 11848, updated on 26-Sep-2021

    Summary

    Official Symbol
    Rhoaprovided by MGI
    Official Full Name
    ras homolog family member Aprovided by MGI
    Primary source
    MGI:MGI:1096342
    See related
    Ensembl:ENSMUSG00000007815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; R; Ar; Arha; Arha1; Arha2
    Summary
    This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in bladder adult (RPKM 88.6), placenta adult (RPKM 81.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rhoa in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108183359..108215142)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108306160..108337943)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108208536..108240270)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene aminomethyltransferase Neighboring gene T cell leukemia translocation altered gene Neighboring gene glutathione peroxidase 1 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Rho GDP-dissociation inhibitor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Roundabout signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in alpha-beta T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apical junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apical junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apolipoprotein A-I-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in beta selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to chemokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebral cortex cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within endothelial tube lumen extension ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within forebrain radial glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within integrin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mitotic cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-substrate adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of intracellular steroid hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within odontogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ossification involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of podosome assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of modification of synaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by endothelin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in trabecula morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transforming protein RhoA
    Names
    aplysia ras-related homolog A
    ras homolog gene family, member A
    NP_001300890.1
    NP_001300891.1
    NP_058082.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313961.1NP_001300890.1  transforming protein RhoA precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161260, BE990465, CX239638
      Consensus CDS
      CCDS23521.1
      UniProtKB/Swiss-Prot
      Q9QUI0
      UniProtKB/TrEMBL
      Q4VAE6
      Related
      ENSMUSP00000141967.2, ENSMUST00000194701.6
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    2. NM_001313962.1NP_001300891.1  transforming protein RhoA precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161260, BE990465
      Consensus CDS
      CCDS23521.1
      UniProtKB/Swiss-Prot
      Q9QUI0
      UniProtKB/TrEMBL
      Q4VAE6
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    3. NM_016802.5NP_058082.2  transforming protein RhoA precursor

      See identical proteins and their annotated locations for NP_058082.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC161260, BC068115, BE990465, BP772032, CX217831, CX239124
      Consensus CDS
      CCDS23521.1
      UniProtKB/Swiss-Prot
      Q9QUI0
      UniProtKB/TrEMBL
      Q4VAE6
      Related
      ENSMUSP00000007959.9, ENSMUST00000007959.14
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108183359..108215142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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