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    Arg2 arginase type II [ Mus musculus (house mouse) ]

    Gene ID: 11847, updated on 19-Mar-2019

    Summary

    Official Symbol
    Arg2provided by MGI
    Official Full Name
    arginase type IIprovided by MGI
    Primary source
    MGI:MGI:1330806
    See related
    Ensembl:ENSMUSG00000021125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AII; AU022422
    Expression
    Biased expression in duodenum adult (RPKM 66.9), small intestine adult (RPKM 62.2) and 8 other tissues See more
    Orthologs

    Genomic context

    See Arg2 in Genome Data Viewer
    Location:
    12; 12 C3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (79130788..79156301)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (80231775..80257288)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9230116L04 gene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H Neighboring gene ribosomal protein large PO subunit pseudogene Neighboring gene predicted gene, 40462 Neighboring gene vesicle transport through interaction with t-SNAREs 1B Neighboring gene retinol dehydrogenase 11 Neighboring gene retinol dehydrogenase 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    arginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    arginase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    arginine catabolic process to ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    arginine catabolic process to ornithine ISO
    Inferred from Sequence Orthology
    more info
     
    arginine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chemokine (C-C motif) ligand 4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chemokine (C-C motif) ligand 5 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-13 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-17 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of macrophage inflammatory protein 1 alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of L-arginine import ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of interleukin-1 beta secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striated muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    urea cycle IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    arginase-2, mitochondrial
    Names
    arginase II
    kidney-type arginase
    non-hepatic arginase
    type II arginase
    NP_033835.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009705.3NP_033835.1  arginase-2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_033835.1

      Status: VALIDATED

      Source sequence(s)
      AC154585, AF032466, DV039756
      Consensus CDS
      CCDS26007.1
      UniProtKB/Swiss-Prot
      O08691
      Related
      ENSMUSP00000021550.6, ENSMUST00000021550.6
      Conserved Domains (1) summary
      cd09989
      Location:26321
      Arginase; Arginase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      79130788..79156301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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