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    Arf6 ADP-ribosylation factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 11845, updated on 19-Mar-2019

    Summary

    Official Symbol
    Arf6provided by MGI
    Official Full Name
    ADP-ribosylation factor 6provided by MGI
    Primary source
    MGI:MGI:99435
    See related
    Ensembl:ENSMUSG00000044147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI788669; AW496366
    Expression
    Ubiquitous expression in duodenum adult (RPKM 90.2), colon adult (RPKM 84.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arf6 in Genome Data Viewer
    Location:
    12; 12 C2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (69372150..69375980)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70473137..70476967)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene 7S RNA 2 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene RIKEN cDNA 5830428M24 gene Neighboring gene predicted gene, 40434

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102530

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of epithelial cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of postsynaptic density structure ISO
    Inferred from Sequence Orthology
    more info
     
    myeloid cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to endosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendritic spine development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of toll-like receptor 4 signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath HDA PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor 6
    NP_031507.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007481.3NP_031507.1  ADP-ribosylation factor 6

      See identical proteins and their annotated locations for NP_031507.1

      Status: VALIDATED

      Source sequence(s)
      AC157822, AV587828, CJ167311
      Consensus CDS
      CCDS25952.1
      UniProtKB/Swiss-Prot
      P62331
      UniProtKB/TrEMBL
      Q3U0D7
      Related
      ENSMUSP00000055862.7, ENSMUST00000050063.8
      Conserved Domains (1) summary
      smart00177
      Location:1175
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      69372150..69375980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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