Format

Send to:

Choose Destination
    • Showing Current items.

    Araf Araf proto-oncogene, serine/threonine kinase [ Mus musculus (house mouse) ]

    Gene ID: 11836, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arafprovided by MGI
    Official Full Name
    Araf proto-oncogene, serine/threonine kinaseprovided by MGI
    Primary source
    MGI:MGI:88065
    See related
    Ensembl:ENSMUSG00000001127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A-Raf; Araf1; AW495444; 1200013E08Rik
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 50.6), adrenal adult (RPKM 43.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Araf in Genome Data Viewer
    Location:
    X A1.3; X 16.3 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (20797784..20860521)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (20425669..20437647)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 11 Neighboring gene predicted gene, 39499 Neighboring gene predicted gene, 39500 Neighboring gene ribonuclease UK114 pseudogene Neighboring gene microRNA 5617 Neighboring gene synapsin I Neighboring gene tissue inhibitor of metalloproteinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immortalization of host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase A-Raf
    Names
    A-Raf proto-oncogene serine/threonine-protein kinase
    proto-oncogene A-Raf
    raf-related oncogene
    v-raf murine sarcoma 3611 viral oncogene homolog 1
    NP_001153117.1
    NP_033833.1
    XP_006527619.1
    XP_006527620.1
    XP_011245731.1
    XP_011245732.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159645.1NP_001153117.1  serine/threonine-protein kinase A-Raf isoform 2

      See identical proteins and their annotated locations for NP_001153117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK039044, BB117083, BB857915
      Consensus CDS
      CCDS53016.1
      UniProtKB/Swiss-Prot
      P04627
      UniProtKB/TrEMBL
      Q8CAD1
      Related
      ENSMUSP00000112513.1, ENSMUST00000120356.7
      Conserved Domains (2) summary
      cd01816
      Location:2091
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00130
      Location:99146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_009703.2NP_033833.1  serine/threonine-protein kinase A-Raf isoform 1

      See identical proteins and their annotated locations for NP_033833.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA960102, AK085823, BB857915
      Consensus CDS
      CCDS40886.1
      UniProtKB/Swiss-Prot
      P04627
      Related
      ENSMUSP00000001155.4, ENSMUST00000001155.10
      Conserved Domains (4) summary
      cd01816
      Location:2091
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00069
      Location:309563
      Pkinase; Protein kinase domain
      pfam00130
      Location:99146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:307571
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      20797784..20860521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247430.2XP_011245732.1  serine/threonine-protein kinase A-Raf isoform X3

      Conserved Domains (3) summary
      cd01816
      Location:57128
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00130
      Location:136183
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:344510
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011247429.2XP_011245731.1  serine/threonine-protein kinase A-Raf isoform X1

      Conserved Domains (4) summary
      cd01816
      Location:57128
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00069
      Location:346600
      Pkinase; Protein kinase domain
      pfam00130
      Location:136183
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:344608
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006527557.3XP_006527620.1  serine/threonine-protein kinase A-Raf isoform X2

      See identical proteins and their annotated locations for XP_006527620.1

      UniProtKB/Swiss-Prot
      P04627
      Conserved Domains (4) summary
      cd01816
      Location:2091
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00069
      Location:309563
      Pkinase; Protein kinase domain
      pfam00130
      Location:99146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:307571
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006527556.3XP_006527619.1  serine/threonine-protein kinase A-Raf isoform X2

      See identical proteins and their annotated locations for XP_006527619.1

      UniProtKB/Swiss-Prot
      P04627
      Conserved Domains (4) summary
      cd01816
      Location:2091
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00069
      Location:309563
      Pkinase; Protein kinase domain
      pfam00130
      Location:99146
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:307571
      PKc_like; Protein Kinases, catalytic domain
    Support Center