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    Aqr aquarius [ Mus musculus (house mouse) ]

    Gene ID: 11834, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aqrprovided by MGI
    Official Full Name
    aquariusprovided by MGI
    Primary source
    MGI:MGI:1276102
    See related
    Ensembl:ENSMUSG00000040383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW495846; mKIAA0560
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.8), limb E14.5 (RPKM 15.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Aqr in Genome Data Viewer
    Location:
    2 E4; 2 57.57 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (114101161..114175339, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (113926908..114001075, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C130080G10 gene Neighboring gene actin, alpha, cardiac muscle 1 Neighboring gene predicted gene, 46757 Neighboring gene nuclear encoded tRNA aspartic acid 2 (anticodon GTC) Neighboring gene microRNA 7002 Neighboring gene zinc finger protein 770 Neighboring gene predicted gene, 31146

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA helicase aquarius
    Names
    intron-binding protein aquarius
    intron-binding protein of 160 kDa
    NP_001277717.1
    NP_033832.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290788.1NP_001277717.1  RNA helicase aquarius isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 3' exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK082873, AK145547, AV245706, BY767970
      Consensus CDS
      CCDS71114.1
      UniProtKB/Swiss-Prot
      Q8CFQ3
      UniProtKB/TrEMBL
      A2AQA7
      Related
      ENSMUSP00000099602.4, ENSMUST00000102543.4
      Conserved Domains (4) summary
      pfam13086
      Location:8051111
      AAA_11; AAA domain
      pfam13245
      Location:808880
      AAA_19; Part of AAA domain
      pfam16399
      Location:18802
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:11191308
      UvrD_C_2; UvrD-like helicase C-terminal domain
    2. NM_009702.3NP_033832.2  RNA helicase aquarius isoform a

      See identical proteins and their annotated locations for NP_033832.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK145547, AL844569, BY767970
      Consensus CDS
      CCDS16565.1
      UniProtKB/Swiss-Prot
      Q8CFQ3
      Related
      ENSMUSP00000047157.6, ENSMUST00000043160.12
      Conserved Domains (4) summary
      pfam13086
      Location:8051111
      AAA_11; AAA domain
      pfam13245
      Location:808880
      AAA_19; Part of AAA domain
      pfam16399
      Location:18802
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:11191308
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      114101161..114175339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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