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    Aplp2 amyloid beta (A4) precursor-like protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 11804, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aplp2provided by MGI
    Official Full Name
    amyloid beta (A4) precursor-like protein 2provided by MGI
    Primary source
    MGI:MGI:88047
    See related
    Ensembl:ENSMUSG00000031996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDEBP; APLP-2; AI790698
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 233.8), bladder adult (RPKM 222.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Aplp2 in Genome Data Viewer
    Location:
    9 A4; 9 16.66 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (31149557..31211862, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (30957142..31019400, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105244993 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene suppression of tumorigenicity 14 (colon carcinoma) Neighboring gene protein CEBPZOS pseudogene Neighboring gene predicted gene, 33535 Neighboring gene predicted gene 7244 Neighboring gene PR domain containing 10 Neighboring gene predicted gene 10910

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    midbrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of epidermal growth factor-activated receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    suckling behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    amyloid-like protein 2
    Names
    CDE1-binding protein CDEBP
    CDEI box-binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102455.2NP_001095925.1  amyloid-like protein 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001095925.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform d.
      Source sequence(s)
      AK150020, BC052396, BY304295, CT025678
      Consensus CDS
      CCDS52749.1
      UniProtKB/TrEMBL
      Q60709
      Related
      ENSMUSP00000072428.7, ENSMUST00000072634.14
      Conserved Domains (6) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:697747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:365547
      APP_E2; E2 domain of amyloid precursor protein
    2. NM_001102456.2NP_001095926.1  amyloid-like protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001095926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform d.
      Source sequence(s)
      AC114542, BC051999, BY304295
      Consensus CDS
      CCDS52748.1
      UniProtKB/Swiss-Prot
      Q06335
      Related
      ENSMUSP00000078694.7, ENSMUST00000079758.8
      Conserved Domains (5) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam02177
      Location:49147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:653703
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:309491
      APP_E2; E2 domain of amyloid precursor protein
    3. NM_001357698.1NP_001344627.1  amyloid-like protein 2 isoform d precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AC114542, CT025678
      Conserved Domains (4) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam10515
      Location:709759
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:365547
      APP_E2; E2 domain of amyloid precursor protein
    4. NM_009691.3NP_033821.1  amyloid-like protein 2 isoform c precursor

      See identical proteins and their annotated locations for NP_033821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform d.
      Source sequence(s)
      AC114542, BC052396, BY304295
      UniProtKB/TrEMBL
      Q64348
      Related
      ENSMUSP00000149023.1, ENSMUST00000217641.1
      Conserved Domains (5) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam02177
      Location:49147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:641691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:309491
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      31149557..31211862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509951.3XP_006510014.1  amyloid-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q61482
      Related
      ENSMUSP00000149732.1, ENSMUST00000213254.1
      Conserved Domains (4) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam10515
      Location:709759
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:365547
      APP_E2; E2 domain of amyloid precursor protein
    2. XM_006509952.1XP_006510015.1  amyloid-like protein 2 isoform X2

      Conserved Domains (6) summary
      smart00006
      Location:1151
      A4_EXTRA; amyloid A4
      pfam00014
      Location:256308
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:194
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:656706
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:96151
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:312494
      APP_E2; E2 domain of amyloid precursor protein
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