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    Xiap X-linked inhibitor of apoptosis [ Mus musculus (house mouse) ]

    Gene ID: 11798, updated on 26-Jul-2021

    Summary

    Official Symbol
    Xiapprovided by MGI
    Official Full Name
    X-linked inhibitor of apoptosisprovided by MGI
    Primary source
    MGI:MGI:107572
    See related
    Ensembl:ENSMUSG00000025860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; I; IL; Bir; Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik
    Summary
    The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Xiap in Genome Data Viewer
    Location:
    X; X A4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41148483..41198541)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42059613..42109664)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (39421013..39462841)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits pseudogene Neighboring gene ribosomal protein S7 pseudogene Neighboring gene zinc finger protein 7 pseudogene Neighboring gene stromal antigen 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase XIAP
    Names
    IAP homolog A
    RING-type E3 ubiquitin transferase XIAP
    X-linked IAP
    baculoviral IAP repeat-containing protein 4
    inhibitor of apoptosis protein 3
    NP_001288568.1
    NP_001288570.1
    NP_033818.2
    XP_006541488.1
    XP_006541490.1
    XP_011249278.1
    XP_011249279.1
    XP_017173848.1
    XP_017173849.1
    XP_017173850.1
    XP_017173851.1
    XP_030107060.1
    XP_030107062.1
    XP_030107063.1
    XP_036017678.1
    XP_036017679.1
    XP_036017680.1
    XP_036017681.1
    XP_036017682.1
    XP_036017683.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301639.1NP_001288568.1  E3 ubiquitin-protein ligase XIAP

      See identical proteins and their annotated locations for NP_001288568.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777
      Consensus CDS
      CCDS30098.1
      UniProtKB/Swiss-Prot
      Q60989
      Related
      ENSMUSP00000110747.3, ENSMUST00000115095.9
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    2. NM_001301641.1NP_001288570.1  E3 ubiquitin-protein ligase XIAP

      See identical proteins and their annotated locations for NP_001288570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI848625, AK041844, AK147447, BC138528, BG091082, BX530028, CD548741, CK389763, CN527460, CN535777
      Consensus CDS
      CCDS30098.1
      UniProtKB/Swiss-Prot
      Q60989
      Related
      ENSMUSP00000061074.4, ENSMUST00000055483.10
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    3. NM_009688.3NP_033818.2  E3 ubiquitin-protein ligase XIAP

      See identical proteins and their annotated locations for NP_033818.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CJ111937, CJ126958, CK389763, CN527460, CN535777
      Consensus CDS
      CCDS30098.1
      UniProtKB/Swiss-Prot
      Q60989
      Related
      ENSMUSP00000110746.2, ENSMUST00000115094.8
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

    RNA

    1. NR_125870.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AI848625, AK041844, AK147447, BB663325, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777
      Related
      ENSMUST00000145065.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      41148483..41198541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318359.3XP_017173848.1  E3 ubiquitin-protein ligase XIAP isoform X2

      UniProtKB/Swiss-Prot
      Q60989
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    2. XM_017318362.3XP_017173851.1  E3 ubiquitin-protein ligase XIAP isoform X2

      UniProtKB/Swiss-Prot
      Q60989
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    3. XM_017318360.3XP_017173849.1  E3 ubiquitin-protein ligase XIAP isoform X2

      UniProtKB/Swiss-Prot
      Q60989
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    4. XM_030251203.2XP_030107063.1  E3 ubiquitin-protein ligase XIAP isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    5. XM_036161787.1XP_036017680.1  E3 ubiquitin-protein ligase XIAP isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    6. XM_036161786.1XP_036017679.1  E3 ubiquitin-protein ligase XIAP isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    7. XM_030251202.2XP_030107062.1  E3 ubiquitin-protein ligase XIAP isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    8. XM_036161788.1XP_036017681.1  E3 ubiquitin-protein ligase XIAP isoform X3

      Conserved Domains (3) summary
      smart00238
      Location:214284
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:80147
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:421470
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    9. XM_011250976.4XP_011249278.1  E3 ubiquitin-protein ligase XIAP isoform X1

      Conserved Domains (4) summary
      smart00238
      Location:214284
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:80147
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:421470
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:487548
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    10. XM_036161790.1XP_036017683.1  E3 ubiquitin-protein ligase XIAP isoform X4

      Conserved Domains (3) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    11. XM_017318361.2XP_017173850.1  E3 ubiquitin-protein ligase XIAP isoform X2

      UniProtKB/Swiss-Prot
      Q60989
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    12. XM_006541427.3XP_006541490.1  E3 ubiquitin-protein ligase XIAP isoform X2

      See identical proteins and their annotated locations for XP_006541490.1

      UniProtKB/Swiss-Prot
      Q60989
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    13. XM_006541425.3XP_006541488.1  E3 ubiquitin-protein ligase XIAP isoform X2

      See identical proteins and their annotated locations for XP_006541488.1

      UniProtKB/Swiss-Prot
      Q60989
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    14. XM_036161785.1XP_036017678.1  E3 ubiquitin-protein ligase XIAP isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    15. XM_030251200.2XP_030107060.1  E3 ubiquitin-protein ligase XIAP isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    16. XM_036161789.1XP_036017682.1  E3 ubiquitin-protein ligase XIAP isoform X4

      Conserved Domains (3) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    17. XM_011250977.4XP_011249279.1  E3 ubiquitin-protein ligase XIAP isoform X2

      See identical proteins and their annotated locations for XP_011249279.1

      UniProtKB/Swiss-Prot
      Q60989
      Conserved Domains (4) summary
      smart00238
      Location:162232
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:2895
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14395
      Location:369418
      UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
      cd16714
      Location:435496
      RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
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