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    Birc3 baculoviral IAP repeat-containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 11796, updated on 23-Jun-2021

    Summary

    Official Symbol
    Birc3provided by MGI
    Official Full Name
    baculoviral IAP repeat-containing 3provided by MGI
    Primary source
    MGI:MGI:1197007
    See related
    Ensembl:ENSMUSG00000032000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; I; HI; MI; cI; MIH; RNF; cIA; Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc2; HIAP2; MIAP1; MIAP2; RNF49; cIAP1; cIAP2; C-IAP2; cIAP-1; cIAP-2; AW107670
    Expression
    Broad expression in spleen adult (RPKM 15.4), large intestine adult (RPKM 9.0) and 20 other tissues See more
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    Genomic context

    See Birc3 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7848698..7873199, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7847468..7873205, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (7848699..7873170, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 123 Neighboring gene microRNA 5618 Neighboring gene baculoviral IAP repeat-containing 2 Neighboring gene yes-associated protein 1 Neighboring gene cilia and flagella associated protein 300

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to tumor necrosis factor IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein polyubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of NIK/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 3
    Names
    IAP-1
    RING-type E3 ubiquitin transferase BIRC3
    apoptosis inhibitor 1
    baculoviral IAP repeat-containing 2
    cellular inhibitor of apoptosis 2
    inhibitor of apoptosis protein 1
    mIAP-1
    NP_031490.2
    XP_006509891.1
    XP_006509892.1
    XP_006509893.1
    XP_006509894.1
    XP_011240654.1
    XP_011240655.1
    XP_036010464.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007464.3NP_031490.2  baculoviral IAP repeat-containing protein 3

      See identical proteins and their annotated locations for NP_031490.2

      Status: VALIDATED

      Source sequence(s)
      AK162108, CA556605, U88908
      Consensus CDS
      CCDS22812.2
      UniProtKB/Swiss-Prot
      O08863
      UniProtKB/TrEMBL
      A2CGA5, Q3TSE5
      Related
      ENSMUSP00000013949.9, ENSMUST00000013949.15
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:549602
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7848698..7873199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509829.5XP_006509892.1  baculoviral IAP repeat-containing protein 3 isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:311381
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:497585
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:433482
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:606659
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    2. XM_006509828.5XP_006509891.1  baculoviral IAP repeat-containing protein 3 isoform X1

      Conserved Domains (4) summary
      smart00238
      Location:333403
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:519607
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:455504
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:628681
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    3. XM_006509831.5XP_006509894.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006509894.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:549602
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    4. XM_011242353.4XP_011240655.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011240655.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:549602
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    5. XM_036154571.1XP_036010464.1  baculoviral IAP repeat-containing protein 3 isoform X3

      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:549602
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    6. XM_006509830.5XP_006509893.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006509893.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:549602
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    7. XM_011242352.4XP_011240654.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011240654.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:549602
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
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