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    Birc3 baculoviral IAP repeat-containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 11796, updated on 31-Jan-2019

    Summary

    Official Symbol
    Birc3provided by MGI
    Official Full Name
    baculoviral IAP repeat-containing 3provided by MGI
    Primary source
    MGI:MGI:1197007
    See related
    Ensembl:ENSMUSG00000032000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc2; HIAP2; MIAP1; MIAP2; RNF49; cIAP1; cIAP2; C-IAP2; cIAP-1; cIAP-2; AW107670
    Expression
    Broad expression in spleen adult (RPKM 15.4), large intestine adult (RPKM 9.0) and 20 other tissues See more

    Genomic context

    See Birc3 in Genome Data Viewer
    Location:
    9; 9 A1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (7848699..7873210, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (7848699..7873170, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 123 Neighboring gene microRNA 5618 Neighboring gene baculoviral IAP repeat-containing 2 Neighboring gene yes-associated protein 1 Neighboring gene cilia and flagella associated protein 300

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein polyubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of NIK/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 3
    Names
    IAP-1
    RING-type E3 ubiquitin transferase BIRC3
    apoptosis inhibitor 1
    baculoviral IAP repeat-containing 2
    cellular inhibitor of apoptosis 2
    inhibitor of apoptosis protein 1
    mIAP-1
    NP_031490.2
    XP_006509891.1
    XP_006509892.1
    XP_006509893.1
    XP_006509894.1
    XP_011240654.1
    XP_011240655.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007464.3NP_031490.2  baculoviral IAP repeat-containing protein 3

      See identical proteins and their annotated locations for NP_031490.2

      Status: VALIDATED

      Source sequence(s)
      AK162108, CA556605, U88908
      Consensus CDS
      CCDS22812.2
      UniProtKB/Swiss-Prot
      O08863
      UniProtKB/TrEMBL
      A2CGA5, Q3TSE5
      Related
      ENSMUSP00000013949.8, ENSMUST00000013949.14
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:551596
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      7848699..7873210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509828.3XP_006509891.1  baculoviral IAP repeat-containing protein 3 isoform X1

      Conserved Domains (4) summary
      smart00238
      Location:333403
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:519607
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:455504
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:630675
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    2. XM_006509829.3XP_006509892.1  baculoviral IAP repeat-containing protein 3 isoform X2

      Conserved Domains (4) summary
      smart00238
      Location:311381
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:497585
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:433482
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:608653
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    3. XM_006509831.3XP_006509894.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006509894.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:551596
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    4. XM_011242353.2XP_011240655.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011240655.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:551596
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    5. XM_006509830.3XP_006509893.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006509893.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:551596
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    6. XM_011242352.2XP_011240654.1  baculoviral IAP repeat-containing protein 3 isoform X3

      See identical proteins and their annotated locations for XP_011240654.1

      UniProtKB/TrEMBL
      A2CGA5
      Conserved Domains (4) summary
      smart00238
      Location:254324
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd08329
      Location:440528
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:376425
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:551596
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
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