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    Atg5 autophagy related 5 [ Mus musculus (house mouse) ]

    Gene ID: 11793, updated on 5-Mar-2019

    Summary

    Official Symbol
    Atg5provided by MGI
    Official Full Name
    autophagy related 5provided by MGI
    Primary source
    MGI:MGI:1277186
    See related
    Ensembl:ENSMUSG00000038160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apg5l; Atg5l; Paddy; C88337; AW319544; 2010107M05Rik; 3110067M24Rik
    Summary
    The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.7), bladder adult (RPKM 9.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atg5 in Genome Data Viewer
    Location:
    10 B2; 10 23.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (44268339..44364299)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (43988164..44084097)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated glutamate (E)-rich protein 5, pseudogene 1 Neighboring gene predicted gene, 40637 Neighboring gene predicted gene, 19229 Neighboring gene microRNA 1929 Neighboring gene predicted gene, 35028 Neighboring gene PR domain containing 1, with ZNF domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to Atg8 ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    C-terminal protein lipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    aggrephagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aggrephagy ISO
    Inferred from Sequence Orthology
    more info
     
    antigen processing and presentation of endogenous antigen IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    antigen processing and presentation of endogenous antigen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy of host cells involved in interaction with symbiont ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to nitrosative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of histone H4-K16 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative stranded viral RNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative thymic T cell selection IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    otolith development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein lipidation involved in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytokine secretion involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Atg12-Atg5-Atg16 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Mitochondria-associated ER Membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001314013.1NP_001300942.1  autophagy protein 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC155642, AK028315, BY126779, CD776008, CX223012
      UniProtKB/Swiss-Prot
      Q99J83
      Conserved Domains (1) summary
      pfam04106
      Location:2166
      APG5; Autophagy protein Apg5
    2. NM_001358596.1NP_001345525.1  autophagy protein 5 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC155642, AK028315, BY126779, CD776008
      Conserved Domains (1) summary
      pfam04106
      Location:79160
      APG5; Autophagy protein Apg5
    3. NM_053069.6NP_444299.1  autophagy protein 5 isoform 1

      See identical proteins and their annotated locations for NP_444299.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC155642, AK028315, BY126779, CD776008
      Consensus CDS
      CCDS23824.1
      UniProtKB/Swiss-Prot
      Q99J83
      Related
      ENSMUSP00000044769.4, ENSMUST00000039286.4
      Conserved Domains (1) summary
      pfam04106
      Location:79270
      APG5; Autophagy protein Apg5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      44268339..44364299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313782.1XP_017169271.1  autophagy protein 5 isoform X2

      Conserved Domains (1) summary
      pfam04106
      Location:79160
      APG5; Autophagy protein Apg5
    2. XM_017313783.1XP_017169272.1  autophagy protein 5 isoform X3

    3. XM_011243108.2XP_011241410.1  autophagy protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011241410.1

      UniProtKB/Swiss-Prot
      Q99J83
      Conserved Domains (1) summary
      pfam04106
      Location:79270
      APG5; Autophagy protein Apg5
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