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    Atg5 autophagy related 5 [ Mus musculus (house mouse) ]

    Gene ID: 11793, updated on 11-Apr-2024

    Summary

    Official Symbol
    Atg5provided by MGI
    Official Full Name
    autophagy related 5provided by MGI
    Primary source
    MGI:MGI:1277186
    See related
    Ensembl:ENSMUSG00000038160 AllianceGenome:MGI:1277186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apg5l; Atg5l; Paddy; 2010107M05Rik; 3110067M24Rik
    Summary
    The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Two transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.7), bladder adult (RPKM 9.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Atg5 in Genome Data Viewer
    Location:
    10 B2; 10 23.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (44144325..44240295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (44268322..44364299)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2323 Neighboring gene spermatogenesis associated glutamate (E)-rich protein 5, pseudogene 1 Neighboring gene coiled-coil domain containing 137 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26535 Neighboring gene STARR-seq mESC enhancer starr_26536 Neighboring gene STARR-positive B cell enhancer ABC_E9786 Neighboring gene predicted gene, 40637 Neighboring gene STARR-positive B cell enhancer ABC_E10605 Neighboring gene STARR-seq mESC enhancer starr_26539 Neighboring gene predicted gene, 19229 Neighboring gene microRNA 1929 Neighboring gene STARR-seq mESC enhancer starr_26543 Neighboring gene predicted gene, 35028 Neighboring gene STARR-positive B cell enhancer ABC_E5133 Neighboring gene STARR-positive B cell enhancer ABC_E6840 Neighboring gene STARR-positive B cell enhancer mm9_chr10:44179511-44179811 Neighboring gene STARR-positive B cell enhancer mm9_chr10:44180013-44180313 Neighboring gene PR domain containing 1, with ZNF domain Neighboring gene STARR-seq mESC enhancer starr_26550

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to Atg8-family ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Atg8-family ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aggrephagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in aggrephagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within antigen processing and presentation of endogenous antigen IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within antigen processing and presentation of endogenous antigen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axonal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in axonal transport IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to nitrosative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_positive_effect chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of autophagic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in negative regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative stranded viral RNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative thymic T cell selection IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within otolith development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein lipidation involved in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein lipidation involved in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cytokine production involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ventricular cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Atg12-Atg5-Atg16 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Atg12-Atg5-Atg16 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Atg12-Atg5-Atg16 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in phagophore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagophore assembly site membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of transferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001314013.2NP_001300942.1  autophagy protein 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC155642
      UniProtKB/Swiss-Prot
      Q99J83
      Conserved Domains (1) summary
      pfam04106
      Location:2166
      APG5; Autophagy protein Apg5
    2. NM_001358596.2NP_001345525.1  autophagy protein 5 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC155642
      Conserved Domains (1) summary
      pfam04106
      Location:79160
      APG5; Autophagy protein Apg5
    3. NM_001428372.1NP_001415301.1  autophagy protein 5 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC155642
      UniProtKB/Swiss-Prot
      Q99J83
    4. NM_001428373.1NP_001415302.1  autophagy protein 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC155642
    5. NM_001428374.1NP_001415303.1  autophagy protein 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC155642
    6. NM_001428375.1NP_001415304.1  autophagy protein 5 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC155642
    7. NM_001428376.1NP_001415305.1  autophagy protein 5 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC155642
    8. NM_001428377.1NP_001415306.1  autophagy protein 5 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC155642
    9. NM_001428378.1NP_001415307.1  autophagy protein 5 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC155642
    10. NM_053069.7NP_444299.1  autophagy protein 5 isoform 1

      See identical proteins and their annotated locations for NP_444299.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AC155642
      Consensus CDS
      CCDS23824.1
      UniProtKB/Swiss-Prot
      Q99J83
      UniProtKB/TrEMBL
      A0A385JBX3
      Related
      ENSMUSP00000044769.5, ENSMUST00000039286.5
      Conserved Domains (1) summary
      pfam04106
      Location:79270
      APG5; Autophagy protein Apg5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      44144325..44240295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313783.3XP_017169272.1  autophagy protein 5 isoform X2

      Conserved Domains (1) summary
      pfam04106
      Location:79189
      APG5; Autophagy protein Apg5
    2. XM_011243108.4XP_011241410.1  autophagy protein 5 isoform X1

      Conserved Domains (1) summary
      pfam04106
      Location:79270
      APG5; Autophagy protein Apg5