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    Apex1 apurinic/apyrimidinic endonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 11792, updated on 23-Mar-2019

    Summary

    Official Symbol
    Apex1provided by MGI
    Official Full Name
    apurinic/apyrimidinic endonuclease 1provided by MGI
    Primary source
    MGI:MGI:88042
    See related
    Ensembl:ENSMUSG00000035960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APE; Apex; HAP1; Ref-1
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 76.3), CNS E14 (RPKM 49.8) and 27 other tissues See more
    Orthologs

    Genomic context

    See Apex1 in Genome Data Viewer
    Location:
    14 C1; 14 26.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (50924949..50927188)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (51544696..51546813)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene kelch-like 33 Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene purine-nucleoside phosphorylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded DNA exodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphodiesterase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphoric diester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    site-specific endodeoxyribonuclease activity, specific for altered base ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance via base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-(apurinic or apyrimidinic site) lyase
    Names
    AP endonuclease 1
    APEN
    APEX nuclease
    redox factor-1
    NP_033817.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009687.2NP_033817.1  DNA-(apurinic or apyrimidinic site) lyase

      See identical proteins and their annotated locations for NP_033817.1

      Status: VALIDATED

      Source sequence(s)
      AC027184, BC052401
      Consensus CDS
      CCDS27027.1
      UniProtKB/Swiss-Prot
      P28352
      UniProtKB/TrEMBL
      Q544Z7
      Related
      ENSMUSP00000042602.5, ENSMUST00000049411.11
      Conserved Domains (1) summary
      cd09087
      Location:61315
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      50924949..50927188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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