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    Apbb2 amyloid beta precursor protein binding family B member 2 [ Mus musculus (house mouse) ]

    Gene ID: 11787, updated on 27-Nov-2024

    Summary

    Official Symbol
    Apbb2provided by MGI
    Official Full Name
    amyloid beta precursor protein binding family B member 2provided by MGI
    Primary source
    MGI:MGI:108405
    See related
    Ensembl:ENSMUSG00000029207 AllianceGenome:MGI:108405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR2L; Zfra; Rirl1; FE65L1; 2310007D03Rik
    Summary
    Predicted to enable amyloid-beta binding activity and molecular adaptor activity. Involved in maintenance of lens transparency and smooth muscle contraction. Acts upstream of or within extracellular matrix organization; generation of neurons; and regulation of apoptotic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 2.9), cerebellum adult (RPKM 2.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Apbb2 in Genome Data Viewer
    Location:
    5 C3.1; 5 34.43 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66456068..66779189, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (66298725..66619064, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene STARR-seq mESC enhancer starr_13286 Neighboring gene STARR-seq mESC enhancer starr_13287 Neighboring gene STARR-seq mESC enhancer starr_13288 Neighboring gene predicted gene 43772 Neighboring gene STARR-seq mESC enhancer starr_13289 Neighboring gene predicted gene 15794 Neighboring gene STARR-seq mESC enhancer starr_13290 Neighboring gene STARR-seq mESC enhancer starr_13291 Neighboring gene NOL1/NOP2/Sun domain family, member 7 Neighboring gene STARR-seq mESC enhancer starr_13293 Neighboring gene STARR-seq mESC enhancer starr_13294 Neighboring gene predicted gene, 52775 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_13303 Neighboring gene STARR-seq mESC enhancer starr_13304 Neighboring gene ubiquitin carboxy-terminal hydrolase L1 Neighboring gene STARR-seq mESC enhancer starr_13305 Neighboring gene LIM and calponin homology domains 1 Neighboring gene STARR-seq mESC enhancer starr_13306 Neighboring gene predicted gene 6517

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in maintenance of lens transparency IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    amyloid beta precursor protein binding family B member 2
    Names
    amyloid beta (A4) precursor protein-binding, family B, member 2
    protein Fe65-like 1
    zinc finger-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201413.2NP_001188342.1  amyloid beta precursor protein binding family B member 2 isoform 2

      See identical proteins and their annotated locations for NP_001188342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS57345.1
      UniProtKB/TrEMBL
      Q3TIZ5, Q3U674
      Related
      ENSMUSP00000123978.3, ENSMUST00000160870.8
      Conserved Domains (3) summary
      cd01271
      Location:582708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416553
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    2. NM_001201414.2NP_001188343.1  amyloid beta precursor protein binding family B member 2 isoform 3

      See identical proteins and their annotated locations for NP_001188343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS57346.1
      UniProtKB/TrEMBL
      E9PWH3, Q3U674
      Related
      ENSMUSP00000124807.2, ENSMUST00000159512.8
      Conserved Domains (3) summary
      cd01271
      Location:562688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    3. NM_001201415.2NP_001188344.1  amyloid beta precursor protein binding family B member 2 isoform 4

      See identical proteins and their annotated locations for NP_001188344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS57344.1
      UniProtKB/TrEMBL
      Q3U674
      Related
      ENSMUSP00000125211.3, ENSMUST00000159786.8
      Conserved Domains (3) summary
      cd01271
      Location:561687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    4. NM_001201416.1NP_001188345.1  amyloid beta precursor protein binding family B member 2 isoform 5

      See identical proteins and their annotated locations for NP_001188345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple coding exons from the 5' end and has an alternate 5' exon compared to variant 1. It initiates translation at a downstream start codon. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC131752
      UniProtKB/TrEMBL
      Q3T9N0
      Related
      ENSMUST00000162955.8
      Conserved Domains (1) summary
      cd01271
      Location:34160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    5. NM_001310626.2NP_001297555.1  amyloid beta precursor protein binding family B member 2 isoform 6

      See identical proteins and their annotated locations for NP_001297555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS80292.1
      UniProtKB/TrEMBL
      Q3TDW6, Q3U674
      Related
      ENSMUSP00000125116.2, ENSMUST00000162366.8
      Conserved Domains (3) summary
      cd01271
      Location:560686
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    6. NM_009686.3NP_033816.1  amyloid beta precursor protein binding family B member 2 isoform 1

      See identical proteins and their annotated locations for NP_033816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS51510.1
      UniProtKB/Swiss-Prot
      Q6DFX8, Q9DBR4
      UniProtKB/TrEMBL
      Q3U674
      Related
      ENSMUSP00000123752.3, ENSMUST00000162349.8
      Conserved Domains (3) summary
      cd01271
      Location:584710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      66456068..66779189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503696.5XP_006503759.1  amyloid beta precursor protein binding family B member 2 isoform X13

      See identical proteins and their annotated locations for XP_006503759.1

      UniProtKB/TrEMBL
      Q3T9N0
      Conserved Domains (1) summary
      cd01271
      Location:34160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    2. XM_006503697.5XP_006503760.1  amyloid beta precursor protein binding family B member 2 isoform X13

      See identical proteins and their annotated locations for XP_006503760.1

      UniProtKB/TrEMBL
      Q3T9N0
      Conserved Domains (1) summary
      cd01271
      Location:34160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    3. XM_036164748.1XP_036020641.1  amyloid beta precursor protein binding family B member 2 isoform X9

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:561687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    4. XM_030254081.2XP_030109941.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:563689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    5. XM_030254078.2XP_030109938.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/Swiss-Prot
      Q6DFX8, Q9DBR4
      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:584710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    6. XM_006503691.5XP_006503754.1  amyloid beta precursor protein binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006503754.1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    7. XM_030254079.2XP_030109939.1  amyloid beta precursor protein binding family B member 2 isoform X2

      UniProtKB/Swiss-Prot
      Q6DFX8, Q9DBR4
      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:584710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    8. XM_006503690.5XP_006503753.1  amyloid beta precursor protein binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006503753.1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    9. XM_030254080.2XP_030109940.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:563689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    10. XM_030254082.2XP_030109942.1  amyloid beta precursor protein binding family B member 2 isoform X10

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:561687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    11. XM_006503694.5XP_006503757.1  amyloid beta precursor protein binding family B member 2 isoform X8

      See identical proteins and their annotated locations for XP_006503757.1

      UniProtKB/TrEMBL
      E9PWH3, Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:562688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    12. XM_006503693.5XP_006503756.1  amyloid beta precursor protein binding family B member 2 isoform X6

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:564690
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396535
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    13. XM_006503692.5XP_006503755.1  amyloid beta precursor protein binding family B member 2 isoform X5

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:582708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    14. XM_017320620.3XP_017176109.1  amyloid beta precursor protein binding family B member 2 isoform X4

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:583709
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    15. XM_011240693.4XP_011238995.1  amyloid beta precursor protein binding family B member 2 isoform X3

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:584710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    16. XM_006503688.5XP_006503751.1  amyloid beta precursor protein binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006503751.1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    17. XM_036164747.1XP_036020640.1  amyloid beta precursor protein binding family B member 2 isoform X7

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:563689
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395534
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    18. XM_036164746.1XP_036020639.1  amyloid beta precursor protein binding family B member 2 isoform X1

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01271
      Location:585711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    19. XM_017320622.3XP_017176111.1  amyloid beta precursor protein binding family B member 2 isoform X12

      Conserved Domains (3) summary
      cd01271
      Location:311437
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:143282
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:1947
      WW; WW domain
    20. XM_036164749.1XP_036020642.1  amyloid beta precursor protein binding family B member 2 isoform X11

      UniProtKB/TrEMBL
      Q3U674
      Conserved Domains (3) summary
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
      cl17171
      Location:585647
      PH-like; Pleckstrin homology-like domain