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    Apbb2 amyloid beta (A4) precursor protein-binding, family B, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 11787, updated on 31-Jan-2019

    Summary

    Official Symbol
    Apbb2provided by MGI
    Official Full Name
    amyloid beta (A4) precursor protein-binding, family B, member 2provided by MGI
    Primary source
    MGI:MGI:108405
    See related
    Ensembl:ENSMUSG00000029207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR2L; Zfra; Rirl1; FE65L1; 2310007D03Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 2.9), cerebellum adult (RPKM 2.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Apbb2 in Genome Data Viewer
    Location:
    5; 5 C3.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (66298725..66618817, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (66693127..67009910, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene predicted gene 15794 Neighboring gene NOL1/NOP2/Sun domain family, member 7 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene ubiquitin carboxy-terminal hydrolase L1 Neighboring gene LIM and calponin homology domains 1 Neighboring gene predicted gene 6517

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone acetyltransferase binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament-based movement NAS
    Non-traceable Author Statement
    more info
    PubMed 
    axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    amyloid-beta A4 precursor protein-binding family B member 2; amyloid beta A4 precursor protein-binding family B member 2
    Names
    zinc finger-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201413.1NP_001188342.1  amyloid-beta A4 precursor protein-binding family B member 2 isoform 2

      See identical proteins and their annotated locations for NP_001188342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC131752, AK167649, BY333882
      Consensus CDS
      CCDS57345.1
      UniProtKB/TrEMBL
      Q3TIZ5
      Related
      ENSMUSP00000123978.2, ENSMUST00000160870.7
      Conserved Domains (3) summary
      cd01271
      Location:582708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416553
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    2. NM_001201414.1NP_001188343.1  amyloid-beta A4 precursor protein-binding family B member 2 isoform 3

      See identical proteins and their annotated locations for NP_001188343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC131752, AK032770, AK153260, BC076587, BY333882
      Consensus CDS
      CCDS57346.1
      UniProtKB/Swiss-Prot
      Q9DBR4
      UniProtKB/TrEMBL
      E9PWH3, Q3U674, Q8BSK4
      Related
      ENSMUSP00000124807.1, ENSMUST00000159512.7
      Conserved Domains (3) summary
      cd01271
      Location:562688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    3. NM_001201415.1NP_001188344.1  amyloid-beta A4 precursor protein-binding family B member 2 isoform 4

      See identical proteins and their annotated locations for NP_001188344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC131752, BC076587, BY333882
      Consensus CDS
      CCDS57344.1
      UniProtKB/Swiss-Prot
      Q9DBR4
      Related
      ENSMUSP00000125211.2, ENSMUST00000159786.7
      Conserved Domains (3) summary
      cd01271
      Location:561687
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    4. NM_001201416.1NP_001188345.1  amyloid-beta A4 precursor protein-binding family B member 2 isoform 5

      See identical proteins and their annotated locations for NP_001188345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple coding exons from the 5' end and has an alternate 5' exon compared to variant 1. It initiates translation at a downstream start codon. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC131752
      UniProtKB/TrEMBL
      Q3T9N0
      Conserved Domains (1) summary
      cd01271
      Location:34160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    5. NM_001310626.1NP_001297555.1  amyloid-beta A4 precursor protein-binding family B member 2 isoform 6

      See identical proteins and their annotated locations for NP_001297555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC123049, AC131752, AC149587, AC165426
      Consensus CDS
      CCDS80292.1
      UniProtKB/TrEMBL
      Q3TDW6
      Related
      ENSMUSP00000125116.1, ENSMUST00000162366.7
      Conserved Domains (3) summary
      cd01271
      Location:560686
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:395532
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain
    6. NM_009686.2NP_033816.1  amyloid-beta A4 precursor protein-binding family B member 2 isoform 1

      See identical proteins and their annotated locations for NP_033816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC131752, AK004792, BY333882
      Consensus CDS
      CCDS51510.1
      UniProtKB/Swiss-Prot
      Q9DBR4
      Related
      ENSMUSP00000123752.2, ENSMUST00000162349.7
      Conserved Domains (3) summary
      cd01271
      Location:584710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:416555
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:292320
      WW; WW domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      66298725..66618817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320622.1XP_017176111.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X8

    2. XM_006503696.3XP_006503759.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X9

      See identical proteins and their annotated locations for XP_006503759.1

      UniProtKB/TrEMBL
      Q3T9N0
      Conserved Domains (1) summary
      cd01271
      Location:34160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    3. XM_006503697.3XP_006503760.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X9

      See identical proteins and their annotated locations for XP_006503760.1

      UniProtKB/TrEMBL
      Q3T9N0
      Conserved Domains (1) summary
      cd01271
      Location:34160
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    4. XM_006503690.3XP_006503753.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006503753.1

      Conserved Domains (3) summary
      cd01271
      Location:585711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    5. XM_017320621.1XP_017176110.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X4

    6. XM_006503694.3XP_006503757.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X7

      See identical proteins and their annotated locations for XP_006503757.1

      UniProtKB/TrEMBL
      E9PWH3
      Conserved Domains (3) summary
      cd01271
      Location:562688
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396533
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    7. XM_006503693.3XP_006503756.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X6

      Conserved Domains (3) summary
      cd01271
      Location:564690
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:396535
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    8. XM_006503692.3XP_006503755.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X5

      Conserved Domains (3) summary
      cd01271
      Location:582708
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417554
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    9. XM_017320620.1XP_017176109.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X3

    10. XM_011240693.2XP_011238995.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X2

      Conserved Domains (3) summary
      cd01271
      Location:584710
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    11. XM_006503688.3XP_006503751.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006503751.1

      Conserved Domains (3) summary
      cd01271
      Location:585711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
    12. XM_006503691.3XP_006503754.1  amyloid beta A4 precursor protein-binding family B member 2 isoform X1

      See identical proteins and their annotated locations for XP_006503754.1

      Conserved Domains (3) summary
      cd01271
      Location:585711
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:417556
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
      pfam00397
      Location:293321
      WW; WW domain
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