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    Ap1s1 adaptor protein complex AP-1, sigma 1 [ Mus musculus (house mouse) ]

    Gene ID: 11769, updated on 6-Jun-2024

    Summary

    Official Symbol
    Ap1s1provided by MGI
    Official Full Name
    adaptor protein complex AP-1, sigma 1provided by MGI
    Primary source
    MGI:MGI:1098244
    See related
    Ensembl:ENSMUSG00000004849 AllianceGenome:MGI:1098244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP19
    Summary
    Acts upstream of or within retrograde transport, endosome to Golgi. Located in terminal bouton. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 34.6), frontal lobe adult (RPKM 34.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ap1s1 in Genome Data Viewer
    Location:
    5 G2; 5 76.13 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137063852..137074917, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137034993..137046108, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26989 Neighboring gene STARR-seq mESC enhancer starr_14633 Neighboring gene STARR-positive B cell enhancer ABC_E10359 Neighboring gene VGF nerve growth factor inducible Neighboring gene STARR-positive B cell enhancer ABC_E4796 Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 1 Neighboring gene STARR-seq mESC enhancer starr_14636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137579031-137579214 Neighboring gene tripartite motif-containing 56

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in trans-Golgi network membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-1 complex subunit sigma-1A
    Names
    HA1 19 kDa subunit
    adapter-related protein complex 1 sigma-1A subunit
    adapter-related protein complex 1 subunit sigma-1A
    adaptor protein complex AP-1 sigma-1A subunit
    adaptor protein complex AP-1 subunit sigma-1A
    adaptor-related protein complex 1 subunit sigma-1A
    adaptor-related protein complex AP-1, sigma 1
    clathrin assembly protein complex 1 sigma-1A small chain
    clathrin coat assembly protein AP19
    golgi adaptor HA1/AP1 adaptin sigma-1A subunit
    sigma 1a subunit of AP-1 clathrin
    sigma-adaptin 1A
    sigma1A-adaptin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420721.1NP_001407650.1  AP-1 complex subunit sigma-1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC147986
      UniProtKB/TrEMBL
      D3Z0D6
    2. NM_001420722.1NP_001407651.1  AP-1 complex subunit sigma-1A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC147986
      UniProtKB/TrEMBL
      D3Z0D6
    3. NM_007457.4NP_031483.1  AP-1 complex subunit sigma-1A isoform 1

      See identical proteins and their annotated locations for NP_031483.1

      Status: VALIDATED

      Source sequence(s)
      AC147986
      Consensus CDS
      CCDS39330.1
      UniProtKB/Swiss-Prot
      P61967
      UniProtKB/TrEMBL
      D3Z0D6
      Related
      ENSMUSP00000106709.2, ENSMUST00000111080.8
      Conserved Domains (1) summary
      cd14831
      Location:3145
      AP1_sigma; AP-1 complex subunit sigma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137063852..137074917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)