U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ap1s1 adaptor protein complex AP-1, sigma 1 [ Mus musculus (house mouse) ]

    Gene ID: 11769, updated on 9-Mar-2023

    Summary

    Go to the top of the page Help
    Official Symbol
    Ap1s1provided by MGI
    Official Full Name
    adaptor protein complex AP-1, sigma 1provided by MGI
    Primary source
    MGI:MGI:1098244
    See related
    Ensembl:ENSMUSG00000004849 AllianceGenome:MGI:1098244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP19
    Summary
    Acts upstream of or within retrograde transport, endosome to Golgi. Located in terminal bouton. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 34.6), frontal lobe adult (RPKM 34.2) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ap1s1 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137063847..137074962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137034993..137046108, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26989 Neighboring gene VGF nerve growth factor inducible Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 1 Neighboring gene tripartite motif-containing 56

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transcription factor AP-1, and the role of Fra-2. Foletta VC. Immunol Cell Biol, 1996 Apr. PMID 8723999
    2. Momordin I, an inhibitor of AP-1, suppressed osteoclastogenesis through inhibition of NF-kappaB and AP-1 and also reduced osteoclast activity and survival. Hwang YH, et al. Biochem Biophys Res Commun, 2005 Nov 25. PMID 16213465
    3. Serum response factor mediates AP-1-dependent induction of the skeletal alpha-actin promoter in ventricular myocytes. Paradis P, et al. J Biol Chem, 1996 May 3. PMID 8631897
    4. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. Moreno E, et al. J Neurosci, 2014 Mar 5. PMID 24599455, Free PMC Article
    5. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Doray B, et al. Mol Biol Cell, 2007 May. PMID 17360967, Free PMC Article

    See all (35) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in basolateral protein secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in melanosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet dense granule organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in trans-Golgi network membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    AP-1 complex subunit sigma-1A
    Names
    HA1 19 kDa subunit
    adapter-related protein complex 1 sigma-1A subunit
    adapter-related protein complex 1 subunit sigma-1A
    adaptor protein complex AP-1 sigma-1A subunit
    adaptor protein complex AP-1 subunit sigma-1A
    adaptor-related protein complex 1 subunit sigma-1A
    adaptor-related protein complex AP-1, sigma 1
    clathrin assembly protein complex 1 sigma-1A small chain
    clathrin coat assembly protein AP19
    golgi adaptor HA1/AP1 adaptin sigma-1A subunit
    sigma 1a subunit of AP-1 clathrin
    sigma-adaptin 1A
    sigma1A-adaptin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007457.3 → NP_031483.1  AP-1 complex subunit sigma-1A

      See identical proteins and their annotated locations for NP_031483.1

      Status: VALIDATED

      Source sequence(s)
      BC052692, BY253222
      Consensus CDS
      CCDS39330.1
      UniProtKB/Swiss-Prot
      P61967
      Related
      ENSMUSP00000106709.2, ENSMUST00000111080.8
      Conserved Domains (1) summary
      cd14831
      Location:3 → 145
      AP1_sigma; AP-1 complex subunit sigma

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137063847..137074962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164745.1 → XP_036020638.1  AP-1 complex subunit sigma-1A isoform X1

      Related
      ENSMUSP00000115941.2, ENSMUST00000150603.8
      Conserved Domains (1) summary
      cd14831
      Location:36 → 178
      AP1_sigma; AP-1 complex subunit sigma

    2. XM_006504348.5 → XP_006504411.1  AP-1 complex subunit sigma-1A isoform X2

      Conserved Domains (1) summary
      cd14831
      Location:21 → 163
      AP1_sigma; AP-1 complex subunit sigma
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61967.1 GenPept UniProtKB/Swiss-Prot:P61967

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous