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    Ap1m2 adaptor protein complex AP-1, mu 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11768, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ap1m2provided by MGI
    Official Full Name
    adaptor protein complex AP-1, mu 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1336974
    See related
    Ensembl:ENSMUSG00000003309 AllianceGenome:MGI:1336974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mu1B; [m]1B; D9Ertd818e
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 27.8), colon adult (RPKM 22.4) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Ap1m2 in Genome Data Viewer
    Location:
    9 A3; 9 7.76 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21205911..21223645, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21294615..21312349, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D Neighboring gene predicted gene, 39302 Neighboring gene solute carrier family 44, member 2 Neighboring gene predicted gene, 36198 Neighboring gene interleukin enhancer binding factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IC
    Inferred by Curator
    more info
    PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in trans-Golgi network membrane IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-1 complex subunit mu-2
    Names
    AP-mu chain family member mu1B
    adaptor protein complex AP-1 subunit mu-2
    adaptor-related protein complex 1 mu-2 subunit
    adaptor-related protein complex 1 subunit mu-2
    adaptor-related protein complex AP-1, mu 2 subunit
    clathrin assembly protein complex 1 medium chain 2
    clathrin assembly protein complex 1 mu-2 medium chain 2
    golgi adaptor HA1/AP1 adaptin mu-2 subunit
    mu-adaptin 2
    mu1B-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110300.2NP_001103770.1  AP-1 complex subunit mu-2 isoform 1

      See identical proteins and their annotated locations for NP_001103770.1

      Status: VALIDATED

      Source sequence(s)
      AC122525
      Consensus CDS
      CCDS52734.1
      UniProtKB/Swiss-Prot
      Q9WVP1
      UniProtKB/TrEMBL
      A0A0R4J1L4, A0A6P5QCR7
      Related
      ENSMUSP00000111093.4, ENSMUST00000115433.11
      Conserved Domains (2) summary
      cd14835
      Location:4142
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
      cl10970
      Location:154423
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    2. NM_001410422.1NP_001397351.1  AP-1 complex subunit mu-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122525
    3. NM_001410423.1NP_001397352.1  AP-1 complex subunit mu-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122525
    4. NM_009678.3NP_033808.2  AP-1 complex subunit mu-2 isoform 2

      See identical proteins and their annotated locations for NP_033808.2

      Status: VALIDATED

      Source sequence(s)
      AC122525
      Consensus CDS
      CCDS22902.1
      UniProtKB/Swiss-Prot
      Q9WVP1
      UniProtKB/TrEMBL
      A0A0R4IZX6, A0A6P5Q685
      Related
      ENSMUSP00000003397.8, ENSMUST00000003397.9
      Conserved Domains (2) summary
      cd14835
      Location:4142
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
      cl10970
      Location:154421
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21205911..21223645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509950.3XP_006510013.1  AP-1 complex subunit mu-2 isoform X2

      Conserved Domains (2) summary
      cl38905
      Location:4107
      longin-like; Longin-like domains
      cl10970
      Location:119386
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    2. XM_006509949.3XP_006510012.1  AP-1 complex subunit mu-2 isoform X1

      Conserved Domains (2) summary
      cl38905
      Location:4107
      longin-like; Longin-like domains
      cl10970
      Location:119388
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)