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    Ap1m1 adaptor-related protein complex AP-1, mu subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 11767, updated on 8-Aug-2021

    Summary

    Official Symbol
    Ap1m1provided by MGI
    Official Full Name
    adaptor-related protein complex AP-1, mu subunit 1provided by MGI
    Primary source
    MGI:MGI:102776
    See related
    Ensembl:ENSMUSG00000003033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP; Clt; mu1; AP47; Adtm; [m]1; mu1A; Cltnm; Adtm1A; AA408894
    Summary
    This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in testis adult (RPKM 143.4), whole brain E14.5 (RPKM 62.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ap1m1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.92 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72993857..73011230)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72240013..72257386)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (74764031..74781278)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 3 Neighboring gene family with sequence similarity 32, member A Neighboring gene predicted gene, 51536 Neighboring gene predicted gene, 51537 Neighboring gene predicted gene, 39197

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in endosome to melanosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in melanosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-1 complex subunit mu-1
    Names
    AP-mu chain family member mu1A
    adapter-related protein complex 1 subunit mu-1
    adaptor protein complex AP-1 mu-1 subunit
    adaptor-related protein complex 1 mu-1 subunit
    clathrin assembly protein complex 1 medium chain 1
    clathrin assembly protein complex 1 mu-1 medium chain 1
    clathrin coat assembly protein AP47
    clathrin coat-associated protein AP47
    golgi adaptor HA1/AP1 adaptin mu-1 subunit
    mu-adaptin 1
    mu1A-adaptin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007456.5NP_031482.1  AP-1 complex subunit mu-1

      See identical proteins and their annotated locations for NP_031482.1

      Status: REVIEWED

      Source sequence(s)
      AC158898, AK148173, CJ075420, CX240144
      Consensus CDS
      CCDS22411.1
      UniProtKB/Swiss-Prot
      P35585
      UniProtKB/TrEMBL
      Q3UG16
      Related
      ENSMUSP00000003117.9, ENSMUST00000003117.15
      Conserved Domains (2) summary
      cd09258
      Location:153422
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
      cd14835
      Location:4142
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72993857..73011230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509538.4XP_006509601.1  AP-1 complex subunit mu-1 isoform X1

      Conserved Domains (2) summary
      cd09258
      Location:127396
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
      cd14835
      Location:1116
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
    2. XM_030243252.2XP_030099112.1  AP-1 complex subunit mu-1 isoform X1

      Conserved Domains (2) summary
      cd09258
      Location:127396
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
      cd14835
      Location:1116
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
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