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    Ap1m1 adaptor-related protein complex AP-1, mu subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 11767, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ap1m1provided by MGI
    Official Full Name
    adaptor-related protein complex AP-1, mu subunit 1provided by MGI
    Primary source
    MGI:MGI:102776
    See related
    Ensembl:ENSMUSG00000003033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP47; mu1A; Cltnm; Adtm1A; AA408894
    Summary
    This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in testis adult (RPKM 143.4), whole brain E14.5 (RPKM 62.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ap1m1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.92 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (72240052..72257385)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (74764031..74781278)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 3 Neighboring gene family with sequence similarity 32, member A Neighboring gene predicted gene, 39197 Neighboring gene predicted gene, 40505

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endosome to melanosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    melanosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cell ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-1 complex subunit mu-1
    Names
    AP-mu chain family member mu1A
    adapter-related protein complex 1 subunit mu-1
    adaptor protein complex AP-1 mu-1 subunit
    adaptor-related protein complex 1 mu-1 subunit
    clathrin assembly protein complex 1 medium chain 1
    clathrin assembly protein complex 1 mu-1 medium chain 1
    clathrin coat assembly protein AP47
    clathrin coat-associated protein AP47
    golgi adaptor HA1/AP1 adaptin mu-1 subunit
    mu-adaptin 1
    mu1A-adaptin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007456.5NP_031482.1  AP-1 complex subunit mu-1

      See identical proteins and their annotated locations for NP_031482.1

      Status: REVIEWED

      Source sequence(s)
      AC158898, AK148173, CJ075420, CX240144
      Consensus CDS
      CCDS22411.1
      UniProtKB/Swiss-Prot
      P35585
      UniProtKB/TrEMBL
      Q3UG16
      Related
      ENSMUSP00000003117.8, ENSMUST00000003117.14
      Conserved Domains (1) summary
      cd09258
      Location:153422
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      72240052..72257385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509538.3XP_006509601.1  AP-1 complex subunit mu-1 isoform X1

      Conserved Domains (1) summary
      cd09258
      Location:127396
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
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