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    Ap1b1 adaptor protein complex AP-1, beta 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11764, updated on 3-Mar-2019

    Summary

    Official Symbol
    Ap1b1provided by MGI
    Official Full Name
    adaptor protein complex AP-1, beta 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1096368
    See related
    Ensembl:ENSMUSG00000009090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adtb1; b2b1660Clo
    Expression
    Ubiquitous expression in kidney adult (RPKM 38.3), large intestine adult (RPKM 36.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ap1b1 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (4947521..5042794)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4886908..4942732)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35321 Neighboring gene predicted gene, 39571 Neighboring gene neurofilament, heavy polypeptide Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene Ewing sarcoma breakpoint region 1 Neighboring gene uncharacterized LOC108167339

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    clathrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane coat IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-1 complex subunit beta-1
    Names
    adaptor protein complex AP-1 subunit beta-1
    adaptor-related protein complex AP-1, beta 1 subunit
    beta-adaptin 1
    beta-prime adaptin
    clathrin assembly protein complex 1 beta large chain
    golgi adaptor HA1/AP1 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243043.1NP_001229972.1  AP-1 complex subunit beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001229972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
      Source sequence(s)
      AK034140, BP765289, CA315828
      UniProtKB/TrEMBL
      Q8CC13
      Conserved Domains (4) summary
      smart00809
      Location:730830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    2. NM_001243044.1NP_001229973.1  AP-1 complex subunit beta-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA003413, AK034140, AK165747, AL645522, BP765289, BY253407
      UniProtKB/TrEMBL
      Q8CC13
      Conserved Domains (5) summary
      smart00809
      Location:723823
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:832945
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:99268
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
    3. NM_001355659.1NP_001342588.1  AP-1 complex subunit beta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645522, BP765289
      Conserved Domains (4) summary
      smart00809
      Location:730830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    4. NM_001355660.1NP_001342589.1  AP-1 complex subunit beta-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645522, BP765289
      Conserved Domains (4) summary
      smart00809
      Location:730830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839949
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    5. NM_007454.3NP_031480.2  AP-1 complex subunit beta-1 isoform 2

      See identical proteins and their annotated locations for NP_031480.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK034140, AK159273, BP765289, BY253407
      Consensus CDS
      CCDS36100.1
      UniProtKB/Swiss-Prot
      O35643
      UniProtKB/TrEMBL
      Q8CC13
      Related
      ENSMUSP00000009234.9, ENSMUST00000009234.15
      Conserved Domains (5) summary
      smart00809
      Location:723823
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:832942
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:99268
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      4947521..5042794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514461.1XP_006514524.1  AP-1 complex subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      Q8CC13
      Conserved Domains (4) summary
      smart00809
      Location:730830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    2. XM_006514463.1XP_006514526.1  AP-1 complex subunit beta-1 isoform X2

      Related
      ENSMUSP00000099134.2, ENSMUST00000101613.2
      Conserved Domains (4) summary
      smart00809
      Location:730830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839949
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
    3. XM_006514462.3XP_006514525.1  AP-1 complex subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006514525.1

      UniProtKB/TrEMBL
      Q8CC13
      Conserved Domains (4) summary
      smart00809
      Location:730830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:5175
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11534
      Adaptin_N; Adaptin N terminal region
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