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    Helb helicase (DNA) B [ Mus musculus (house mouse) ]

    Gene ID: 117599, updated on 31-Jan-2019

    Summary

    Official Symbol
    Helbprovided by MGI
    Official Full Name
    helicase (DNA) Bprovided by MGI
    Primary source
    MGI:MGI:2152895
    See related
    Ensembl:ENSMUSG00000020228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI447783; D10Ertd664e
    Expression
    Ubiquitous expression in liver E14 (RPKM 4.4), thymus adult (RPKM 4.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Helb in Genome Data Viewer
    Location:
    10 D2; 10 67.94 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (120083608..120113015, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (119520664..119550021, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene glutamate receptor interacting protein 1, opposite strand 2 Neighboring gene predicted gene, 46207 Neighboring gene glutamate receptor interacting protein 1, opposite strand 1 Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene predicted gene, 34545 Neighboring gene predicted gene, 40781

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent 5'-3' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP-dependent 5'-3' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA-dependent ATP-dependent DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    single-stranded DNA-dependent ATP-dependent DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA helicase B
    NP_536694.2
    XP_017169270.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080446.2NP_536694.2  DNA helicase B

      See identical proteins and their annotated locations for NP_536694.2

      Status: VALIDATED

      Source sequence(s)
      AB048542, AK131122
      Consensus CDS
      CCDS24203.1
      UniProtKB/Swiss-Prot
      Q6NVF4
      Related
      ENSMUSP00000020449.5, ENSMUST00000020449.11
      Conserved Domains (3) summary
      TIGR01448
      Location:273922
      recD_rel; helicase, putative, RecD/TraA family
      cl21455
      Location:435635
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl22977
      Location:855901
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      120083608..120113015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313781.1XP_017169270.1  DNA helicase B isoform X1

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