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    FASN2 Fatty acid synthase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117361, updated on 8-Oct-2018

    Summary

    Official Symbol
    FASN2provided by FlyBase
    Official Full Name
    Fatty acid synthase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0042627
    Locus tag
    Dmel_CG3524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3524; Dmel\CG3524; DM_7295849; FAS; FAS-mb; FASN[CG3524]; FAS[CG3524]; mFAS; v(2)k05816

    Genomic context

    See FASN2 in Genome Data Viewer
    Location:
    23C5-23C5; 2-8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3043947..3056143)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3043947..3056143)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U5 at 23D Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA Like U Neighboring gene Fatty acid synthase 1 Neighboring gene toucan Neighboring gene Protein phosphatase D6

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    fatty acid synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to sucrose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cuticle hydrocarbon biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methyl-branched fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fatty acid synthase 2
    Names
    CG3524-PA
    CG3524-PB
    FASN2-PA
    FASN2-PB
    fatty acid synthase, methyl-branched specific
    mbCHC-specific FAS
    methyl-branched specific FAS
    v(2)k05816
    NP_001259986.1
    NP_647613.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3043947..3056143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273057.2NP_001259986.1  fatty acid synthase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB21
      Related
      FBpp0307370, FBtr0335386
      Conserved Domains (11) summary
      cd05195
      Location:14731761
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:17802018
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:20312083
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:14711761
      PKS_ER; Enoylreductase
      COG3321
      Location:151043
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:18423
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:381498
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:8751072
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:518835
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:12631429
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:21592408
      Abhydrolase; alpha/beta hydrolases
    2. NM_139356.2NP_647613.1  fatty acid synthase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQL6
      Related
      FBpp0077342, FBtr0077657
      Conserved Domains (11) summary
      cd05195
      Location:14731761
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:17802018
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:20312083
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:14711761
      PKS_ER; Enoylreductase
      COG3321
      Location:151043
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:18423
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:381498
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:8751072
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:518835
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:12631429
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:21592407
      Abhydrolase; alpha/beta hydrolases
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