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    Amd1 S-adenosylmethionine decarboxylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 11702, updated on 27-Nov-2024

    Summary

    Official Symbol
    Amd1provided by MGI
    Official Full Name
    S-adenosylmethionine decarboxylase 1provided by MGI
    Primary source
    MGI:MGI:88004
    See related
    Ensembl:ENSMUSG00000075232 AllianceGenome:MGI:88004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Amd-1; SAMDC; SAMDC 1; AdoMetDC; adoMetDC1
    Summary
    Predicted to enable adenosylmethionine decarboxylase activity; identical protein binding activity; and putrescine binding activity. Predicted to be involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cranium; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 38.2), liver E14 (RPKM 34.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Amd1 in Genome Data Viewer
    Location:
    10 B1; 10 21.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40163454..40178184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40287458..40302188, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26413 Neighboring gene general transcription factor IIIC, polypeptide 6, alpha Neighboring gene small nucleolar RNA, C/D box 3A Neighboring gene STARR-positive B cell enhancer ABC_E2319 Neighboring gene STARR-seq mESC enhancer starr_26414 Neighboring gene STARR-positive B cell enhancer ABC_E136 Neighboring gene STARR-positive B cell enhancer ABC_E5126 Neighboring gene STARR-positive B cell enhancer ABC_E6831 Neighboring gene predicted gene 8948 Neighboring gene STARR-seq mESC enhancer starr_26416 Neighboring gene STARR-seq mESC enhancer starr_26417 Neighboring gene STARR-seq mESC enhancer starr_26418 Neighboring gene cyclin dependent kinase 19 Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC91044, MGC102468

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenosylmethionine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenosylmethionine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenosylmethionine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables putrescine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables putrescine binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polyamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    S-adenosylmethionine decarboxylase proenzyme 1
    Names
    adoMetDC 1
    NP_033795.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009665.5NP_033795.1  S-adenosylmethionine decarboxylase proenzyme 1

      See identical proteins and their annotated locations for NP_033795.1

      Status: VALIDATED

      Source sequence(s)
      AC142273, AK146840
      Consensus CDS
      CCDS48544.1
      UniProtKB/Swiss-Prot
      P0DMN7, P31154, P82184, Q58E47
      Related
      ENSMUSP00000159133.2, ENSMUST00000238969.2
      Conserved Domains (1) summary
      pfam01536
      Location:4325
      SAM_decarbox; Adenosylmethionine decarboxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      40163454..40178184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)