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    ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [ Homo sapiens (human) ]

    Gene ID: 116983, updated on 27-Nov-2024

    Summary

    Official Symbol
    ACAP3provided by HGNC
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 3provided by HGNC
    Primary source
    HGNC:HGNC:16754
    See related
    Ensembl:ENSG00000131584 AllianceGenome:HGNC:16754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENTB5
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to act upstream of or within neuron migration and regulation of neuron projection development. Predicted to be located in endosome membrane and growth cone. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in skin (RPKM 16.2), brain (RPKM 12.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ACAP3 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1292391..1307930, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (723917..739479, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1227771..1243310, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 J2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:1199775-1200974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1207366-1207874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1207875-1208381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1208382-1208889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 49 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 50 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1210080-1210718 Neighboring gene long intergenic non-protein coding RNA 1786 Neighboring gene MPRA-validated peak7 silencer Neighboring gene sodium channel epithelial 1 subunit delta Neighboring gene CEB15 minisatellite repeat instability region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1223369-1223916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1223917-1224463 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1224736-1225308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 51 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1227773-1228318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1232563-1233499 Neighboring gene microRNA 6726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1237151-1237752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1237753-1238352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1238353-1238953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1238954-1239553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1239554-1240154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 52 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 53 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 54 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 55 Neighboring gene small nucleolar RNA, C/D box 167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 56 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 57 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 58 Neighboring gene pseudouridine synthase like 1 Neighboring gene microRNA 6727 Neighboring gene integrator complex subunit 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1716

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
    Names
    centaurin-beta-5
    cnt-b5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030649.3NP_085152.2  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

      See identical proteins and their annotated locations for NP_085152.2

      Status: VALIDATED

      Source sequence(s)
      AB051503, AL139287, BC051194
      Consensus CDS
      CCDS19.2
      UniProtKB/Swiss-Prot
      B1AMF5, Q5TA42, Q5TA43, Q86UT3, Q96P50, Q9BSR9, Q9C0E7
      Related
      ENSP00000346733.5, ENST00000354700.10
      Conserved Domains (7) summary
      cd07637
      Location:16215
      BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
      cd00204
      Location:701788
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:271367
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:269363
      PH; PH domain
      pfam01412
      Location:403521
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:705756
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:702733
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1292391..1307930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005244715.3XP_005244772.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X6

      Related
      ENSP00000321139.4, ENST00000353662.4
      Conserved Domains (7) summary
      cd00204
      Location:668755
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:271367
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:269363
      PH; PH domain
      pfam01412
      Location:403521
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:672723
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:669700
      ANK; ANK repeat [structural motif]
      cl12013
      Location:16215
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_011540608.3XP_011538910.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X4

      Conserved Domains (7) summary
      cd00204
      Location:679766
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:249345
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:247341
      PH; PH domain
      pfam01412
      Location:381499
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:683734
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:680711
      ANK; ANK repeat [structural motif]
      cl12013
      Location:16200
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_011540609.3XP_011538911.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X5

      Conserved Domains (7) summary
      cd00204
      Location:678765
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:281377
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:279373
      PH; PH domain
      pfam01412
      Location:413531
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:682733
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:679710
      ANK; ANK repeat [structural motif]
      cl12013
      Location:16225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_011540606.3XP_011538908.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

      Conserved Domains (7) summary
      cd00204
      Location:711798
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:281377
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:279373
      PH; PH domain
      pfam01412
      Location:413531
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:715766
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:712743
      ANK; ANK repeat [structural motif]
      cl12013
      Location:16225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_024452993.2XP_024308761.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X3

      Conserved Domains (5) summary
      cd07637
      Location:16215
      BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
      cd00204
      Location:701788
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:271367
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:702733
      ANK; ANK repeat [structural motif]
      pfam01412
      Location:403521
      ArfGap; Putative GTPase activating protein for Arf
    6. XM_011540607.2XP_011538909.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X2

      Conserved Domains (7) summary
      cd00204
      Location:711798
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:281377
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:279373
      PH; PH domain
      pfam01412
      Location:413531
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:715766
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:712743
      ANK; ANK repeat [structural motif]
      cl12013
      Location:16225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    7. XM_005244717.4XP_005244774.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X7

      Conserved Domains (5) summary
      cd00204
      Location:360447
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01412
      Location:62180
      ArfGap; Putative GTPase activating protein for Arf
      pfam13637
      Location:364415
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:361392
      ANK; ANK repeat [structural motif]
      cl17171
      Location:126
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      723917..739479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334177.1XP_054190152.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X6

    2. XM_054334175.1XP_054190150.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X4

    3. XM_054334176.1XP_054190151.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X5

    4. XM_054334172.1XP_054190147.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

    5. XM_054334174.1XP_054190149.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X3

    6. XM_054334173.1XP_054190148.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X2

    7. XM_054334178.1XP_054190153.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X7