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    Gfer growth factor, augmenter of liver regeneration [ Mus musculus (house mouse) ]

    Gene ID: 11692, updated on 28-Oct-2018

    Summary

    Official Symbol
    Gferprovided by MGI
    Official Full Name
    growth factor, augmenter of liver regenerationprovided by MGI
    Primary source
    MGI:MGI:107757
    See related
    Ensembl:ENSMUSG00000040888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Alr; ERV1
    Expression
    Ubiquitous expression in testis adult (RPKM 40.9), colon adult (RPKM 27.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gfer in Genome Data Viewer
    Location:
    17 A3.3; 17 12.48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (24693189..24696228, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24830136..24833101, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 598 Neighboring gene synaptogyrin 3 Neighboring gene NADPH oxidase organizer 1 Neighboring gene transducin (beta)-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    flavin-linked sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    flavin-linked sulfhydryl oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    liver regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    FAD-linked sulfhydryl oxidase ALR
    Names
    augmenter of liver regeneration
    growth factor, erv1-like (augmenter of liver regeneration)
    NP_075527.2
    XP_006523575.2
    XP_006523576.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023040.3NP_075527.2  FAD-linked sulfhydryl oxidase ALR

      See identical proteins and their annotated locations for NP_075527.2

      Status: VALIDATED

      Source sequence(s)
      AA123449, AB041561, AK146579, BE691392
      Consensus CDS
      CCDS28492.1
      UniProtKB/Swiss-Prot
      P56213
      Related
      ENSMUSP00000049186.8, ENSMUST00000046839.8
      Conserved Domains (1) summary
      cl02107
      Location:79194
      Evr1_Alr; Erv1 / Alr family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      24693189..24696228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523512.3XP_006523575.2  FAD-linked sulfhydryl oxidase ALR isoform X1

      Conserved Domains (1) summary
      cl02107
      Location:79183
      Evr1_Alr; Erv1 / Alr family
    2. XM_006523513.3XP_006523576.2  FAD-linked sulfhydryl oxidase ALR isoform X2

      Conserved Domains (1) summary
      cl02107
      Location:79144
      Evr1_Alr; Erv1 / Alr family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212443.1: Suppressed sequence

      Description
      NM_212443.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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