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    LEAP2 liver enriched antimicrobial peptide 2 [ Homo sapiens (human) ]

    Gene ID: 116842, updated on 5-Mar-2024

    Summary

    Official Symbol
    LEAP2provided by HGNC
    Official Full Name
    liver enriched antimicrobial peptide 2provided by HGNC
    Primary source
    HGNC:HGNC:29571
    See related
    Ensembl:ENSG00000164406 MIM:611373; AllianceGenome:HGNC:29571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LEAP-2
    Summary
    This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in liver (RPKM 158.3), small intestine (RPKM 13.5) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    Location:
    5q31.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132873668..132875046)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133393425..133394803)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132209360..132210738)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 192 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:132201613-132202812 Neighboring gene growth differentiation factor 9 Neighboring gene ubiquinol-cytochrome c reductase complex III subunit VII Neighboring gene ALF transcription elongation factor 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 50 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: UQCRQ

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    liver-expressed antimicrobial peptide 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052971.3NP_443203.1  liver-expressed antimicrobial peptide 2 precursor

      See identical proteins and their annotated locations for NP_443203.1

      Status: REVIEWED

      Source sequence(s)
      AC004500, AJ409065, BX443829
      Consensus CDS
      CCDS4163.1
      UniProtKB/Swiss-Prot
      D3DQ91, Q969E1
      UniProtKB/TrEMBL
      Q7Z5F5
      Related
      ENSP00000296877.2, ENST00000296877.3
      Conserved Domains (1) summary
      pfam07359
      Location:177
      LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      132873668..132875046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      133393425..133394803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)