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    Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) [ Mus musculus (house mouse) ]

    Gene ID: 11677, updated on 3-Feb-2019

    Summary

    Official Symbol
    Akr1b3provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member B3 (aldose reductase)provided by MGI
    Primary source
    MGI:MGI:1353494
    See related
    Ensembl:ENSMUSG00000001642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AR; ALR2; Ahr1; Ahr-1; Aldr1; Akr1b1; Aldor1
    Expression
    Broad expression in bladder adult (RPKM 290.1), heart adult (RPKM 93.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See Akr1b3 in Genome Data Viewer
    Location:
    6 14.87 cM; 6 B1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (34303930..34317489, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (34253930..34267489, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 13855 Neighboring gene predicted gene, 32533 Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene cancer susceptibility candidate 4 pseudogene Neighboring gene RIO kinase 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    alcohol dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alditol:NADP+ 1-oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alditol:NADP+ 1-oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alditol:NADP+ 1-oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    glyceraldehyde oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular hyperosmotic salinity response ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to methylglyoxal ISO
    Inferred from Sequence Orthology
    more info
     
    daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    inner medullary collecting duct development ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric collecting duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monosaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    naphthalene metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of urine volume IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of urine volume IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to water deprivation ISO
    Inferred from Sequence Orthology
    more info
     
    retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    sorbitol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Schmidt-Lanterman incisure ISO
    Inferred from Sequence Orthology
    more info
     
    Schwann cell microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    mast cell granule ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    paranodal junction ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane bounded cell projection cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aldose reductase
    Names
    aldehyde reductase 1
    aldo-keto reductase family 1, member B1 (aldose reductase)
    NP_033788.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009658.3NP_033788.3  aldose reductase

      See identical proteins and their annotated locations for NP_033788.3

      Status: VALIDATED

      Source sequence(s)
      AK164682, AV301527, BY749711
      Consensus CDS
      CCDS19990.1
      UniProtKB/Swiss-Prot
      P45376
      UniProtKB/TrEMBL
      Q3UDY1
      Related
      ENSMUSP00000100045.4, ENSMUST00000102980.10
      Conserved Domains (2) summary
      COG0656
      Location:1297
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:8289
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      34303930..34317489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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