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    Lsm10 U7 snRNP-specific Sm-like protein LSM10 [ Mus musculus (house mouse) ]

    Gene ID: 116748, updated on 23-Nov-2023

    Summary

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    Official Symbol
    Lsm10provided by MGI
    Official Full Name
    U7 snRNP-specific Sm-like protein LSM10provided by MGI
    Primary source
    MGI:MGI:2151045
    See related
    Ensembl:ENSMUSG00000050188 AllianceGenome:MGI:2151045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables histone pre-mRNA DCP binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and positive regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in Cajal body. Predicted to be part of U7 snRNP and cytoplasmic U snRNP body. Predicted to be active in nuclear body. Orthologous to human LSM10 (LSM10, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 18.4), mammary gland adult (RPKM 16.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lsm10 in Genome Data Viewer
    Location:
    4 D2.2; 4 59.88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_04 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125990355..125992377)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126096562..126098584)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene serine/threonine kinase 40 Neighboring gene eva-1 homolog B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. Pillai RS, et al. EMBO J, 2001 Oct 1. PMID 11574479, Free PMC Article
    2. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Yang XC, et al. Mol Cell Biol, 2009 Aug. PMID 19470752, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U7 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U7 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone pre-mRNA DCP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone pre-mRNA DCP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of U7 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of cytoplasmic U snRNP body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U7 snRNA-associated Sm-like protein LSm10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163266.1 → NP_001156738.1  U7 snRNA-associated Sm-like protein LSm10

      See identical proteins and their annotated locations for NP_001156738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK143443, AL627101, BE944742
      Consensus CDS
      CCDS18642.1
      UniProtKB/Swiss-Prot
      Q8QZX5
      UniProtKB/TrEMBL
      Q3UPL7
      Related
      ENSMUSP00000136585.2, ENSMUST00000179323.2
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10

    2. NM_138721.2 → NP_620046.1  U7 snRNA-associated Sm-like protein LSm10

      See identical proteins and their annotated locations for NP_620046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK143443, AL627101, BE944742
      Consensus CDS
      CCDS18642.1
      UniProtKB/Swiss-Prot
      Q8QZX5
      UniProtKB/TrEMBL
      Q3UPL7
      Related
      ENSMUSP00000061913.8, ENSMUST00000055575.8
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      125990355..125992377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502686.3 → XP_006502749.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      See identical proteins and their annotated locations for XP_006502749.1

      UniProtKB/Swiss-Prot
      Q8QZX5
      UniProtKB/TrEMBL
      Q3UPL7
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10

    2. XM_006502687.4 → XP_006502750.1  U7 snRNA-associated Sm-like protein LSm10 isoform X1

      See identical proteins and their annotated locations for XP_006502750.1

      UniProtKB/Swiss-Prot
      Q8QZX5
      UniProtKB/TrEMBL
      Q3UPL7
      Conserved Domains (1) summary
      cd01733
      Location:8 → 85
      LSm10; Like-Sm protein 10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZX5.1 GenPept UniProtKB/Swiss-Prot:Q8QZX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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