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    Vps4a vacuolar protein sorting 4A [ Mus musculus (house mouse) ]

    Gene ID: 116733, updated on 22-Aug-2021

    Summary

    Official Symbol
    Vps4aprovided by MGI
    Official Full Name
    vacuolar protein sorting 4Aprovided by MGI
    Primary source
    MGI:MGI:1890520
    See related
    Ensembl:ENSMUSG00000031913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI325971; AW553189; 4930589C15Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 44.5), CNS E18 (RPKM 32.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Vps4a in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107757901..107772392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107031269..107045760)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (109555226..109569656)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene syntrophin, basic 2 Neighboring gene predicted gene, 22085 Neighboring gene predicted gene 16208 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene peptide deformylase (mitochondrial) Neighboring gene component of oligomeric golgi complex 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC11698

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in abscission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosomal vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in late endosomal microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multivesicular body assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleus organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vacuole organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle budding from membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle uncoating ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral budding from plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in viral budding from plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vacuolar membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    vacuolar protein sorting-associated protein 4A
    Names
    vacuolar protein sorting protein 4a
    NP_569053.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_126165.2NP_569053.1  vacuolar protein sorting-associated protein 4A

      See identical proteins and their annotated locations for NP_569053.1

      Status: VALIDATED

      Source sequence(s)
      AC123868, AK159117, BU610346, DV663224
      Consensus CDS
      CCDS40463.1
      UniProtKB/Swiss-Prot
      Q8VEJ9
      Related
      ENSMUSP00000034388.10, ENSMUST00000034388.10
      Conserved Domains (3) summary
      PTZ00454
      Location:4348
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam09336
      Location:374434
      Vps4_C; Vps4 C terminal oligomerization domain
      cd19521
      Location:121291
      RecA-like_VPS4; ATPase domain of vacuolar protein sorting-associated protein 4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      107757901..107772392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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