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    Aldh2 aldehyde dehydrogenase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 11669, updated on 5-Mar-2019

    Summary

    Official Symbol
    Aldh2provided by MGI
    Official Full Name
    aldehyde dehydrogenase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:99600
    See related
    Ensembl:ENSMUSG00000029455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ahd5; ALDHI; Ahd-5; AHD-M1; ALDH-E2
    Expression
    Broad expression in adrenal adult (RPKM 574.9), liver adult (RPKM 432.0) and 18 other tissues See more
    Orthologs

    Genomic context

    See Aldh2 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (121566027..121593824, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122017696..122043833, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NADH binding ISO
    Inferred from Sequence Orthology
    more info
     
    aldehyde dehydrogenase (NAD) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    aldehyde dehydrogenase (NAD) activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aldehyde dehydrogenase, mitochondrial
    Names
    ALDH class 2
    NP_001295379.1
    NP_033786.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308450.1NP_001295379.1  aldehyde dehydrogenase, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate 3' exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK043506, AK165032, CO039039
      Consensus CDS
      CCDS84951.1
      UniProtKB/TrEMBL
      A0A0G2JEU1, Q544B1
      Related
      ENSMUSP00000142906.1, ENSMUST00000129753.7
      Conserved Domains (1) summary
      cd07141
      Location:33471
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    2. NM_009656.4NP_033786.1  aldehyde dehydrogenase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_033786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK163452, AK165032, AW050084
      Consensus CDS
      CCDS19638.1
      UniProtKB/Swiss-Prot
      P47738
      UniProtKB/TrEMBL
      Q544B1
      Related
      ENSMUSP00000031411.8, ENSMUST00000031411.14
      Conserved Domains (2) summary
      cd07141
      Location:33513
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
      PLN02466
      Location:3518
      PLN02466; aldehyde dehydrogenase family 2 member

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      121566027..121593824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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