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    MRPL53 mitochondrial ribosomal protein L53 [ Homo sapiens (human) ]

    Gene ID: 116540, updated on 5-May-2024


    Official Symbol
    MRPL53provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L53provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000204822 MIM:611857; AllianceGenome:HGNC:16684
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mL53; L53MT
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]
    Ubiquitous expression in fat (RPKM 22.6), adrenal (RPKM 21.9) and 25 other tissues See more
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    Genomic context

    See MRPL53 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (74471982..74472680, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (74480549..74481247, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74699109..74699807, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene INO80B-WBP1 readthrough (NMD candidate) Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:74685443-74685950 Neighboring gene WW domain binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11664 Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene Sharpr-MPRA regulatory region 2309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16061 Neighboring gene coiled-coil domain containing 142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16065 Neighboring gene tetratricopeptide repeat domain 31

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    large ribosomal subunit protein mL53
    39S ribosomal protein L53, mitochondrial
    mitochondrial large ribosomal subunit protein mL53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053050.5NP_444278.1  large ribosomal subunit protein mL53

      See identical proteins and their annotated locations for NP_444278.1

      Status: REVIEWED

      Source sequence(s)
      BC012163, BQ014848
      Consensus CDS
      ENSP00000258105.7, ENST00000258105.8
      Conserved Domains (1) summary
      MRP_L53; 39S ribosomal protein L53/MRP-L53

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly


    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      74471982..74472680 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0


    1. NC_060926.1 Alternate T2T-CHM13v2.0

      74480549..74481247 complement
      GenBank, FASTA, Sequence Viewer (Graphics)