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    Akt2 thymoma viral proto-oncogene 2 [ Mus musculus (house mouse) ]

    Gene ID: 11652, updated on 28-Nov-2021

    Summary

    Official Symbol
    Akt2provided by MGI
    Official Full Name
    thymoma viral proto-oncogene 2provided by MGI
    Primary source
    MGI:MGI:104874
    See related
    Ensembl:ENSMUSG00000004056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKB; PKBbeta; AW554154; 2410016A19Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 40.3), mammary gland adult (RPKM 35.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Akt2 in Genome Data Viewer
    Location:
    7 A3; 7 15.94 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27290977..27340251)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27591552..27640826)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (28376579..28424472)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310022A10 gene Neighboring gene predicted gene, 45975 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 38973 Neighboring gene mitogen-activated protein kinase kinase kinase 10 Neighboring gene tetratricopeptide repeat domain 9B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC14031

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to high light intensity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of long-chain fatty acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within peripheral nervous system myelin maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of glucose import IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_negative_effect protein localization to nucleus EXP
    Inferred from Experiment
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retinal rod cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RAC-beta serine/threonine-protein kinase
    Names
    PKB beta
    RAC-PK-beta
    protein kinase Akt-2
    protein kinase B, beta
    NP_001103678.1
    NP_001318037.1
    NP_001318038.1
    NP_031460.1
    XP_006539544.1
    XP_006539545.1
    XP_006539546.1
    XP_030097857.1
    XP_030097858.1
    XP_030097859.1
    XP_030097860.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110208.2NP_001103678.1  RAC-beta serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_001103678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK028871, AK158792, BM899551, CJ159088
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95, Q8CE74
      Related
      ENSMUSP00000103981.3, ENSMUST00000108344.9
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    2. NM_001331108.1NP_001318037.1  RAC-beta serine/threonine-protein kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC074312, BM899551
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    3. NM_001331109.1NP_001318038.1  RAC-beta serine/threonine-protein kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK028871, BC040377, BM899551
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95, Q8CE74
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    4. NM_007434.4NP_031460.1  RAC-beta serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_031460.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK028871, AK158792, BM899551, CJ152468
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95, Q8CE74
      Related
      ENSMUSP00000052103.6, ENSMUST00000051356.12
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27290977..27340251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539482.3XP_006539545.1  RAC-beta serine/threonine-protein kinase isoform X2

      See identical proteins and their annotated locations for XP_006539545.1

      Conserved Domains (2) summary
      cd05595
      Location:113435
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cl17171
      Location:468
      PH-like; Pleckstrin homology-like domain
    2. XM_030241998.1XP_030097858.1  RAC-beta serine/threonine-protein kinase isoform X1

      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    3. XM_030241997.2XP_030097857.1  RAC-beta serine/threonine-protein kinase isoform X1

      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    4. XM_006539483.2XP_006539546.1  RAC-beta serine/threonine-protein kinase isoform X2

      See identical proteins and their annotated locations for XP_006539546.1

      Conserved Domains (2) summary
      cd05595
      Location:113435
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cl17171
      Location:468
      PH-like; Pleckstrin homology-like domain
    5. XM_030241999.1XP_030097859.1  RAC-beta serine/threonine-protein kinase isoform X1

      Related
      ENSMUSP00000103980.2, ENSMUST00000108343.8
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    6. XM_006539481.5XP_006539544.1  RAC-beta serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006539544.1

      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    7. XM_030242000.2XP_030097860.1  RAC-beta serine/threonine-protein kinase isoform X1

      Related
      ENSMUSP00000132141.2, ENSMUST00000167435.8
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
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