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    Akap1 A kinase (PRKA) anchor protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 11640, updated on 31-Jan-2019

    Summary

    Official Symbol
    Akap1provided by MGI
    Official Full Name
    A kinase (PRKA) anchor protein 1provided by MGI
    Primary source
    MGI:MGI:104729
    See related
    Ensembl:ENSMUSG00000018428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akap; AKAP84; C76494; C81186; DAKAP1; AKAP121; S-AKAP84
    Expression
    Broad expression in testis adult (RPKM 171.5), heart adult (RPKM 26.9) and 15 other tissues See more
    Orthologs

    Genomic context

    See Akap1 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (88830792..88864586, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (88692106..88725900, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 2 Neighboring gene RIKEN cDNA 0610039H22 gene Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene serine carboxypeptidase 1, opposite strand Neighboring gene serine carboxypeptidase 1 Neighboring gene elongin B-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 1, mitochondrial
    Names
    D-AKAP-1
    PRKA1
    S-AKAP
    a kinase anchor protein 1, mitochondrial
    dual specificity A-kinase-anchoring protein 1
    protein kinase A-anchoring protein 1
    spermatid A-kinase anchor protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042541.1NP_001036006.1  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_001036006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK020371, AK132749, AL596180, CJ167452
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      O08715
      UniProtKB/TrEMBL
      Q9CTT7
      Related
      ENSMUSP00000018572.4, ENSMUST00000018572.10
      Conserved Domains (3) summary
      smart00333
      Location:710768
      TUDOR; Tudor domain
      cd00105
      Location:565625
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:658780
      TUDOR; Tudor domain
    2. NM_009648.2NP_033778.2  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_033778.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AK020371, AK132749, AL596180
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      O08715
      UniProtKB/TrEMBL
      Q9CTT7
      Related
      ENSMUSP00000103536.1, ENSMUST00000107903.7
      Conserved Domains (3) summary
      smart00333
      Location:710768
      TUDOR; Tudor domain
      cd00105
      Location:565625
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:658780
      TUDOR; Tudor domain

    RNA

    1. NR_104310.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK132749, AK186415, AW985969, BC065135
      Related
      ENSMUST00000143720.7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      88830792..88864586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_879507.2 RNA Sequence

    2. XR_388330.2 RNA Sequence

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187003.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      1976122..2009712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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