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    Akap1 A kinase (PRKA) anchor protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 11640, updated on 23-Jun-2021

    Summary

    Official Symbol
    Akap1provided by MGI
    Official Full Name
    A kinase (PRKA) anchor protein 1provided by MGI
    Primary source
    MGI:MGI:104729
    See related
    Ensembl:ENSMUSG00000018428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AKA; DAK; Akap; S-AK; AKAP84; C76494; C81186; DAKAP1; AKAP121; S-AKAP84
    Expression
    Broad expression in testis adult (RPKM 171.5), heart adult (RPKM 26.9) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Akap1 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88721618..88755426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88830792..88864596, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (88692106..88725900, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 2 Neighboring gene RIKEN cDNA 0610039H22 gene Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene serine carboxypeptidase 1, opposite strand Neighboring gene predicted gene, 23507 Neighboring gene serine carboxypeptidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 1, mitochondrial
    Names
    D-AKAP-1
    PRKA1
    S-AKAP
    a kinase anchor protein 1, mitochondrial
    dual specificity A-kinase-anchoring protein 1
    protein kinase A-anchoring protein 1
    spermatid A-kinase anchor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042541.1NP_001036006.1  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_001036006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK020371, AK132749, AL596180, CJ167452
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      O08715
      UniProtKB/TrEMBL
      Q9CTT7
      Related
      ENSMUSP00000018572.5, ENSMUST00000018572.11
      Conserved Domains (3) summary
      smart00333
      Location:710768
      TUDOR; Tudor domain
      cd00105
      Location:565625
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:658780
      TUDOR; Tudor domain
    2. NM_009648.2NP_033778.2  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_033778.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AK020371, AK132749, AL596180
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      O08715
      UniProtKB/TrEMBL
      Q9CTT7
      Related
      ENSMUSP00000103536.2, ENSMUST00000107903.8
      Conserved Domains (3) summary
      smart00333
      Location:710768
      TUDOR; Tudor domain
      cd00105
      Location:565625
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:658780
      TUDOR; Tudor domain

    RNA

    1. NR_104310.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK132749, AK186415, AW985969, BC065135
      Related
      ENSMUST00000143720.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      88721618..88755426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245481.2XP_030101341.1  A-kinase anchor protein 1, mitochondrial isoform X1

    RNA

    1. XR_388330.4 RNA Sequence

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