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    Ak2 adenylate kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 11637, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ak2provided by MGI
    Official Full Name
    adenylate kinase 2provided by MGI
    Primary source
    MGI:MGI:87978
    See related
    Ensembl:ENSMUSG00000028792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ak-2; D4Ertd220e
    Expression
    Ubiquitous expression in large intestine adult (RPKM 35.1), subcutaneous fat pad adult (RPKM 34.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ak2 in Genome Data Viewer
    Location:
    4 D2.2; 4 62.62 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (128993224..129011529)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (128670509..128688773)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33901 Neighboring gene antizyme inhibitor 2 Neighboring gene predicted gene 15904 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene ring finger protein 19B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the Ak2 gene: The Ak2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs from Annotation Pipeline: 259 organisms have orthologs with human gene Ak2
    • Orthologs

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to nucleobase-containing compound kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotransferase activity, phosphate group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ADP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    dATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sperm mitochondrial sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adenylate kinase 2, mitochondrial
    Names
    AK 2
    ATP-AMP transphosphorylase 2
    ATP:AMP phosphotransferase
    adenylate monophosphate kinase
    NP_001029138.1
    NP_058591.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033966.4NP_001029138.1  adenylate kinase 2, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_001029138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL607086
      Consensus CDS
      CCDS18680.1
      UniProtKB/Swiss-Prot
      Q9WTP6
      Related
      ENSMUSP00000030583.6, ENSMUST00000030583.12
      Conserved Domains (2) summary
      cd01428
      Location:17219
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam00406
      Location:20204
      ADK; Adenylate kinase
    2. NM_016895.4NP_058591.2  adenylate kinase 2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_058591.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which has a shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AL607086
      Consensus CDS
      CCDS18679.1
      UniProtKB/Swiss-Prot
      Q9WTP6
      Related
      ENSMUSP00000099664.4, ENSMUST00000102604.10
      Conserved Domains (2) summary
      cd01428
      Location:17219
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam00406
      Location:20204
      ADK; Adenylate kinase

    RNA

    1. NR_138540.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' exon. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL607086, BM937796

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      128993224..129011529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_376293.2 RNA Sequence

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187023.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      588499..606864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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