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    Ak2 adenylate kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 11637, updated on 1-Mar-2024

    Summary

    Official Symbol
    Ak2provided by MGI
    Official Full Name
    adenylate kinase 2provided by MGI
    Primary source
    MGI:MGI:87978
    See related
    Ensembl:ENSMUSG00000028792 AllianceGenome:MGI:87978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ak-2; D4Ertd220e
    Summary
    Predicted to enable adenylate kinase activity. Predicted to contribute to nucleobase-containing compound kinase activity. Predicted to be involved in ATP metabolic process and purine nucleotide metabolic process. Predicted to act upstream of or within phosphorylation. Located in sperm mitochondrial sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 35.1), subcutaneous fat pad adult (RPKM 34.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ak2 in Genome Data Viewer
    Location:
    4 D2.2; 4 62.62 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128887017..128905322)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128993224..129011529)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57685 Neighboring gene antizyme inhibitor 2 Neighboring gene predicted gene 15904 Neighboring gene STARR-positive B cell enhancer mm9_chr4:128639609-128639910 Neighboring gene STARR-positive B cell enhancer ABC_E3515 Neighboring gene STARR-positive B cell enhancer ABC_E122 Neighboring gene STARR-positive B cell enhancer ABC_E6222 Neighboring gene STARR-positive B cell enhancer ABC_E7990 Neighboring gene STARR-seq mESC enhancer starr_11473 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10260 Neighboring gene STARR-positive B cell enhancer ABC_E3516 Neighboring gene ring finger protein 19B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to nucleobase-containing compound kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotransferase activity, phosphate group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm mitochondrial sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adenylate kinase 2, mitochondrial
    Names
    AK 2
    ATP-AMP transphosphorylase 2
    ATP:AMP phosphotransferase
    adenylate monophosphate kinase
    NP_001029138.1
    NP_058591.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033966.4NP_001029138.1  adenylate kinase 2, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_001029138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL607086
      Consensus CDS
      CCDS18680.1
      UniProtKB/Swiss-Prot
      A2A820, Q3THT3, Q3TI11, Q3TKI6, Q8C7I9, Q9CY37, Q9WTP6
      Related
      ENSMUSP00000030583.7, ENSMUST00000030583.13
      Conserved Domains (2) summary
      cd01428
      Location:17219
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam00406
      Location:20204
      ADK; Adenylate kinase
    2. NM_016895.4NP_058591.2  adenylate kinase 2, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_058591.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which has a shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AL607086
      Consensus CDS
      CCDS18679.1
      UniProtKB/Swiss-Prot
      Q9WTP6
      Related
      ENSMUSP00000099664.5, ENSMUST00000102604.11
      Conserved Domains (2) summary
      cd01428
      Location:17219
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam00406
      Location:20204
      ADK; Adenylate kinase

    RNA

    1. NR_138540.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' exon. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL607086, BM937796

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      128887017..128905322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)