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    ADCYAP1 adenylate cyclase activating polypeptide 1 [ Homo sapiens (human) ]

    Gene ID: 116, updated on 17-Jun-2024

    Summary

    Official Symbol
    ADCYAP1provided by HGNC
    Official Full Name
    adenylate cyclase activating polypeptide 1provided by HGNC
    Primary source
    HGNC:HGNC:241
    See related
    Ensembl:ENSG00000141433 MIM:102980; AllianceGenome:HGNC:241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PACAP
    Summary
    This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
    Expression
    Biased expression in appendix (RPKM 6.6), brain (RPKM 5.7) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ADCYAP1 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (904411..912172)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (1058628..1066467)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (904872..912173)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene Neighboring gene MPRA-validated peak3036 silencer Neighboring gene uncharacterized LOC124904340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:907717-908438 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:909161-909882 Neighboring gene long intergenic non-protein coding RNA 1904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:949337-949911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:949912-950485 Neighboring gene uncharacterized LOC107985165 Neighboring gene Sharpr-MPRA regulatory region 14540 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:1011056-1012255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:1015112-1015673

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat PACAP27-induced release of CCL5 inhibits HIV-1 Tat-mediated toxicity in human astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126852

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pituitary adenylate cyclase activating polypeptide activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pituitary adenylate cyclase activating polypeptide activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
     
    Process Evidence Code Pubs
    involved_in activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine (C-C motif) ligand 5 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of growth hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    pituitary adenylate cyclase-activating polypeptide
    Names
    adenylate cyclase activating polypeptide 1 (pituitary)
    prepro-PACAP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099733.2NP_001093203.1  pituitary adenylate cyclase-activating polypeptide preproprotein

      See identical proteins and their annotated locations for NP_001093203.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AP000894, BC093837, DC320719
      Consensus CDS
      CCDS11825.1
      UniProtKB/Swiss-Prot
      B2R7N4, P18509, Q52LQ0
      Related
      ENSP00000411658.3, ENST00000450565.8
      Conserved Domains (2) summary
      smart00070
      Location:83109
      GLUCA; Glucagon like hormones
      pfam00123
      Location:132158
      Hormone_2; Peptide hormone
    2. NM_001117.5NP_001108.2  pituitary adenylate cyclase-activating polypeptide preproprotein

      See identical proteins and their annotated locations for NP_001108.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AP000894, BC093837
      Consensus CDS
      CCDS11825.1
      UniProtKB/Swiss-Prot
      B2R7N4, P18509, Q52LQ0
      Related
      ENSP00000462647.1, ENST00000579794.1
      Conserved Domains (2) summary
      smart00070
      Location:83109
      GLUCA; Glucagon like hormones
      pfam00123
      Location:132158
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      904411..912172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258081.5XP_005258138.2  pituitary adenylate cyclase-activating polypeptide isoform X2

      UniProtKB/TrEMBL
      B7Z222
      Conserved Domains (2) summary
      smart00070
      Location:222248
      GLUCA; Glucagon like hormones
      pfam00123
      Location:271297
      Hormone_2; Peptide hormone
    2. XM_047437288.1XP_047293244.1  pituitary adenylate cyclase-activating polypeptide isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      1058628..1066467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318174.1XP_054174149.1  pituitary adenylate cyclase-activating polypeptide isoform X3

    2. XM_054318173.1XP_054174148.1  pituitary adenylate cyclase-activating polypeptide isoform X1