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    Afp alpha fetoprotein [ Mus musculus (house mouse) ]

    Gene ID: 11576, updated on 26-Jun-2024

    Summary

    Official Symbol
    Afpprovided by MGI
    Official Full Name
    alpha fetoproteinprovided by MGI
    Primary source
    MGI:MGI:87951
    See related
    Ensembl:ENSMUSG00000054932 AllianceGenome:MGI:87951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable fatty acid binding activity and zinc ion binding activity. Acts upstream of or within SMAD protein signal transduction; ovulation from ovarian follicle; and progesterone metabolic process. Located in cytoplasm and extracellular space. Is expressed in several structures, including amniotic fluid; egg cylinder; gut; liver and biliary system; and metanephros. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E18 (RPKM 8164.6), liver E14 (RPKM 4926.5) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Afp in Genome Data Viewer
    Location:
    5 E1; 5 44.77 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90638573..90656766)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90490714..90508907)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35999 Neighboring gene albumin (Alb) 5' regulatory region Neighboring gene albumin Neighboring gene alpha fetoprotein (Afp) 5' regulatory region Neighboring gene afamin Neighboring gene zinc finger, BED domain containing 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-glucuronidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-fetoprotein
    Names
    alpha-1-fetoprotein
    alpha-fetoglobulin
    alpha-foetoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007423.4NP_031449.3  alpha-fetoprotein precursor

      See identical proteins and their annotated locations for NP_031449.3

      Status: VALIDATED

      Source sequence(s)
      AV105248, BC066206, BY773400
      Consensus CDS
      CCDS19413.1
      UniProtKB/Swiss-Prot
      P02772, Q3UJD0
      UniProtKB/TrEMBL
      Q8BK56
      Related
      ENSMUSP00000041006.4, ENSMUST00000042755.7
      Conserved Domains (1) summary
      smart00103
      Location:400590
      ALBUMIN; serum albumin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      90638573..90656766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)