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    Aebp2 AE binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 11569, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aebp2provided by MGI
    Official Full Name
    AE binding protein 2provided by MGI
    Primary source
    MGI:MGI:1338038
    See related
    Ensembl:ENSMUSG00000030232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU023766; B230313N05Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.4), CNS E11.5 (RPKM 7.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Aebp2 in Genome Data Viewer
    Location:
    6; 6 G2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (140622454..140678472)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (140571184..140625939)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 5 Neighboring gene predicted gene 5051 Neighboring gene predicted gene, 38918 Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene predicted gene, 30524

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein AEBP2
    Names
    adipocyte enhancer-binding protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005605.2NP_001005605.1  zinc finger protein AEBP2 isoform 1

      See identical proteins and their annotated locations for NP_001005605.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC133098, AK045838
      Consensus CDS
      CCDS20673.1
      UniProtKB/Swiss-Prot
      Q9Z248
      Related
      ENSMUSP00000084896.4, ENSMUST00000087614.10
      Conserved Domains (3) summary
      COG5048
      Location:210332
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:308334
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001309436.1NP_001296365.1  zinc finger protein AEBP2 isoform 4

      See identical proteins and their annotated locations for NP_001296365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR, alternate 3' coding region and cause translation initiation at a downstream start codon, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and distinct C-terminus, compared to isoform 1. Both variants 4 and 5 encode the same protein (isoform 4).
      Source sequence(s)
      AC133098, AK045838
      Consensus CDS
      CCDS80631.1
      UniProtKB/Swiss-Prot
      Q9Z248
      Related
      ENSMUSP00000125479.1, ENSMUST00000161335.7
      Conserved Domains (2) summary
      COG5048
      Location:3110
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:3757
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001309437.1NP_001296366.1  zinc finger protein AEBP2 isoform 4

      See identical proteins and their annotated locations for NP_001296366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR, alternate 3' coding region and cause translation initiation at a downstream start codon, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and distinct C-terminus, compared to isoform 1. Both variants 4 and 5 encode the same protein (isoform 4).
      Source sequence(s)
      AC133098, AK045838
      Consensus CDS
      CCDS80631.1
      UniProtKB/Swiss-Prot
      Q9Z248
      Related
      ENSMUSP00000124148.1, ENSMUST00000160836.7
      Conserved Domains (2) summary
      COG5048
      Location:3110
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:3757
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_009637.4NP_033767.2  zinc finger protein AEBP2 isoform 3

      See identical proteins and their annotated locations for NP_033767.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB221647, AC133098
      Consensus CDS
      CCDS39689.2
      UniProtKB/Swiss-Prot
      Q9Z248
      Related
      ENSMUSP00000092993.5, ENSMUST00000095350.10
      Conserved Domains (3) summary
      COG5048
      Location:210332
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:308334
      zf-H2C2_2; Zinc-finger double domain
    5. NM_178803.2NP_848918.1  zinc finger protein AEBP2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
      Source sequence(s)
      AC133098
      Consensus CDS
      CCDS20674.1
      UniProtKB/Swiss-Prot
      Q9Z248
      Related
      ENSMUSP00000032359.8, ENSMUST00000032359.14
      Conserved Domains (2) summary
      COG5048
      Location:3110
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:3757
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      140622454..140678472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506909.3XP_006506972.1  zinc finger protein AEBP2 isoform X4

      See identical proteins and their annotated locations for XP_006506972.1

      UniProtKB/Swiss-Prot
      Q9Z248
      Conserved Domains (2) summary
      COG5048
      Location:3110
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:3757
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_006506905.3XP_006506968.1  zinc finger protein AEBP2 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:210332
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:308334
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006506906.1XP_006506969.1  zinc finger protein AEBP2 isoform X2

      See identical proteins and their annotated locations for XP_006506969.1

      UniProtKB/Swiss-Prot
      Q9Z248
      Conserved Domains (3) summary
      COG5048
      Location:210332
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:308334
      zf-H2C2_2; Zinc-finger double domain
    4. XM_017321346.1XP_017176835.1  zinc finger protein AEBP2 isoform X3

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