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    Parp1 poly (ADP-ribose) polymerase family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 11545, updated on 26-Sep-2021

    Summary

    Official Symbol
    Parp1provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 1provided by MGI
    Primary source
    MGI:MGI:1340806
    See related
    Ensembl:ENSMUSG00000026496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; pa; sP; Adp; PARP; PPOL; ARTD1; Adprp; Adprt1; C80510; msPARP; parp-1; sPARP-1; AI893648; 5830444G22Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 60.8), CNS E14 (RPKM 38.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Parp1 in Genome Data Viewer
    Location:
    1 H4; 1 84.44 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180396456..180428564)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180568891..180600999)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182499106..182531385)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mechanosensory transduction mediator Neighboring gene predicted gene, 31986 Neighboring gene microRNA 6904 Neighboring gene predicted gene, 53485 Neighboring gene lin-9 DREAM MuvB core complex component

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD DNA ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD+ ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein ADP-ribosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein ADP-ribosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein ADP-ribosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response, detection of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to superoxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitochondrial DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial DNA repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of telomere maintenance via telomere lengthening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-glutamic acid poly-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myofibroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of single strand break repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of single strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein auto-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein modification process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein poly-ADP-ribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein poly-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein poly-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of SMAD protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of single strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction involved in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in voluntary musculoskeletal movement IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
    ADP-ribosyltransferase diphtheria toxin-like 1
    ADPRT 1
    DNA ADP-ribosyltransferase PARP1
    NAD(+) ADP-ribosyltransferase 1
    poly(ADP-ribose) polymerase
    poly[ADP-ribose] synthase 1
    poly[ADP-ribose] synthetase 1
    protein poly-ADP-ribosyltransferase PARP1
    NP_031441.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007415.3NP_031441.2  poly [ADP-ribose] polymerase 1

      See identical proteins and their annotated locations for NP_031441.2

      Status: VALIDATED

      Source sequence(s)
      AC167020, AK159433, CJ153239
      Consensus CDS
      CCDS15569.1
      UniProtKB/TrEMBL
      Q921K2
      Related
      ENSMUSP00000027777.7, ENSMUST00000027777.12
      Conserved Domains (6) summary
      cd08001
      Location:543645
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:91010
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:6621006
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:389462
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:1287
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:281332
      PADR1; PADR1 (NUC008) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180396456..180428564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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