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    LRRC42 leucine rich repeat containing 42 [ Homo sapiens (human) ]

    Gene ID: 115353, updated on 5-Mar-2024

    Summary

    Official Symbol
    LRRC42provided by HGNC
    Official Full Name
    leucine rich repeat containing 42provided by HGNC
    Primary source
    HGNC:HGNC:28792
    See related
    Ensembl:ENSG00000116212 AllianceGenome:HGNC:28792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ167A19.4
    Expression
    Ubiquitous expression in thyroid (RPKM 11.3), testis (RPKM 10.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1p32.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (53946350..53968168)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (53829258..53851077)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54412023..54433841)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904180 Neighboring gene iodothyronine deiodinase 1 Neighboring gene uncharacterized LOC124904181 Neighboring gene intraflagellar transport 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 913 Neighboring gene Sharpr-MPRA regulatory region 3629 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:54422389-54423588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:54424449-54425155 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 12 Neighboring gene low density lipoprotein receptor class A domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 42

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256409.2NP_001243338.1  leucine-rich repeat-containing protein 42

      See identical proteins and their annotated locations for NP_001243338.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK095767, CB851494, CX783955
      Consensus CDS
      CCDS585.1
      UniProtKB/Swiss-Prot
      D3DQ46, Q8N2Q8, Q9Y546
      Related
      ENSP00000360421.3, ENST00000371370.8
      Conserved Domains (2) summary
      sd00034
      Location:175202
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl26161
      Location:167272
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_052940.5NP_443172.1  leucine-rich repeat-containing protein 42

      See identical proteins and their annotated locations for NP_443172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK075201, CB851494, CX783955
      Consensus CDS
      CCDS585.1
      UniProtKB/Swiss-Prot
      D3DQ46, Q8N2Q8, Q9Y546
      Related
      ENSP00000318185.4, ENST00000319223.8
      Conserved Domains (2) summary
      sd00034
      Location:175202
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl26161
      Location:167272
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      53946350..53968168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710328.5XP_006710391.1  leucine-rich repeat-containing protein 42 isoform X1

      See identical proteins and their annotated locations for XP_006710391.1

      UniProtKB/Swiss-Prot
      D3DQ46, Q8N2Q8, Q9Y546
      Conserved Domains (2) summary
      sd00034
      Location:175202
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl26161
      Location:167272
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      53829258..53851077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334161.1XP_054190136.1  leucine-rich repeat-containing protein 42 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ46, Q8N2Q8, Q9Y546
    2. XM_054334162.1XP_054190137.1  leucine-rich repeat-containing protein 42 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ46, Q8N2Q8, Q9Y546