Format

Send to:

Choose Destination
    • Showing Current items.

    Adk adenosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 11534, updated on 31-Aug-2021

    Summary

    Official Symbol
    Adkprovided by MGI
    Official Full Name
    adenosine kinaseprovided by MGI
    Primary source
    MGI:MGI:87930
    See related
    Ensembl:ENSMUSG00000039197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Ak; AI255373; AI987814; 2310026J05Rik; 5033405D03Rik
    Expression
    Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adk in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21102622..21498637)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21052574..21448569)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (21871855..22267769)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene vinculin Neighboring gene uncharacterized protein C3orf14 homolog pseudogene Neighboring gene adaptor-related protein complex 3, mu 1 subunit Neighboring gene VISTA enhancer mm1738 Neighboring gene predicted gene, 30363 Neighboring gene K(lysine) acetyltransferase 6B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6593

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables adenosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables adenosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deoxyadenosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenosine kinase
    Names
    adenosine 5'-phosphotransferase
    NP_001229970.1
    NP_598840.1
    XP_006518503.1
    XP_006518504.1
    XP_030103470.1
    XP_030103471.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243041.1NP_001229970.1  adenosine kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI194759, AK151863
      Consensus CDS
      CCDS88589.1
      UniProtKB/Swiss-Prot
      P55264
      Related
      ENSMUSP00000153089.2, ENSMUST00000224069.2
      Conserved Domains (1) summary
      cl00192
      Location:12344
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    2. NM_134079.4NP_598840.1  adenosine kinase isoform 1

      See identical proteins and their annotated locations for NP_598840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC163681, AI194759, AK032871, AK160264, AY540996
      Consensus CDS
      CCDS26862.1
      UniProtKB/Swiss-Prot
      P55264
      UniProtKB/TrEMBL
      Q8BMC5
      Related
      ENSMUSP00000047665.10, ENSMUST00000045376.11
      Conserved Domains (1) summary
      cl00192
      Location:28360
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21102622..21498637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518441.4XP_006518504.1  adenosine kinase isoform X3

      Conserved Domains (1) summary
      cl00192
      Location:28241
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    2. XM_006518440.5XP_006518503.1  adenosine kinase isoform X1

      Conserved Domains (1) summary
      cl00192
      Location:28241
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    3. XM_030247610.2XP_030103470.1  adenosine kinase isoform X2

      Conserved Domains (1) summary
      cl00192
      Location:12225
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    4. XM_030247611.1XP_030103471.1  adenosine kinase isoform X4

      Conserved Domains (1) summary
      cl00192
      Location:12225
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    Support Center