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    Adk adenosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 11534, updated on 17-Feb-2019

    Summary

    Official Symbol
    Adkprovided by MGI
    Official Full Name
    adenosine kinaseprovided by MGI
    Primary source
    MGI:MGI:87930
    See related
    Ensembl:ENSMUSG00000039197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ak; AI255373; AI987814; 2310026J05Rik; 5033405D03Rik
    Expression
    Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues See more
    Orthologs

    Genomic context

    See Adk in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (21052574..21448569)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (21871855..22267769)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene vinculin Neighboring gene predicted gene, 30274 Neighboring gene adaptor-related protein complex 3, mu 1 subunit Neighboring gene predicted gene, 30363 Neighboring gene K(lysine) acetyltransferase 6B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6593

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adenosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    dATP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    purine ribonucleoside salvage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenosine kinase
    Names
    adenosine 5'-phosphotransferase
    NP_001229970.1
    NP_598840.1
    XP_006518503.1
    XP_006518504.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243041.1NP_001229970.1  adenosine kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI194759, AK151863
      UniProtKB/Swiss-Prot
      P55264
      Related
      ENSMUSP00000153089.1, ENSMUST00000224069.1
      Conserved Domains (1) summary
      cl00192
      Location:12344
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    2. NM_134079.4NP_598840.1  adenosine kinase isoform 1

      See identical proteins and their annotated locations for NP_598840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC163681, AI194759, AK032871, AK160264, AY540996
      Consensus CDS
      CCDS26862.1
      UniProtKB/Swiss-Prot
      P55264
      UniProtKB/TrEMBL
      Q8BMC5
      Related
      ENSMUSP00000047665.9, ENSMUST00000045376.10
      Conserved Domains (1) summary
      cl00192
      Location:28360
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      21052574..21448569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518440.3XP_006518503.1  adenosine kinase isoform X1

      Conserved Domains (1) summary
      cl00192
      Location:28241
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    2. XM_006518441.3XP_006518504.1  adenosine kinase isoform X2

      Conserved Domains (1) summary
      cl00192
      Location:28241
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
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