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    Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 11532, updated on 31-Jan-2019

    Summary

    Official Symbol
    Adh5provided by MGI
    Official Full Name
    alcohol dehydrogenase 5 (class III), chi polypeptideprovided by MGI
    Primary source
    MGI:MGI:87929
    See related
    Ensembl:ENSMUSG00000028138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adh3; Adh-5; GSNOR
    Expression
    Ubiquitous expression in liver E18 (RPKM 86.3), CNS E11.5 (RPKM 59.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See Adh5 in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (138437200..138455499)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (138106128..138118463)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 6 (class V), pseudogene 1 Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553 Neighboring gene microRNA 1956 Neighboring gene eukaryotic translation initiation factor 4E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    S-(hydroxymethyl)glutathione dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    S-(hydroxymethyl)glutathione dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    alcohol dehydrogenase (NAD) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alcohol dehydrogenase (NAD) activity ISO
    Inferred from Sequence Orthology
    more info
     
    alcohol dehydrogenase activity, zinc-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    formaldehyde dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ethanol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ethanol oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    formaldehyde catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    formaldehyde catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-cysteine S-nitrosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nitrosative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to redox state ISO
    Inferred from Sequence Orthology
    more info
     
    retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alcohol dehydrogenase class-3
    Names
    ADH-B2
    FALDH
    FDH
    GSH-FDH
    S-(hydroxymethyl)glutathione dehydrogenase
    S-nitrosoglutathione reductase
    alcohol dehydrogenase 2
    alcohol dehydrogenase B2
    alcohol dehydrogenase class-III
    glutathione-dependent formaldehyde dehydrogenase
    NP_001275507.1
    NP_031436.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288578.1NP_001275507.1  alcohol dehydrogenase class-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, which results in translation intiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK076507, CF172597
      UniProtKB/Swiss-Prot
      P28474
      Conserved Domains (1) summary
      cl16912
      Location:1251
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    2. NM_007410.3NP_031436.2  alcohol dehydrogenase class-3 isoform 1

      See identical proteins and their annotated locations for NP_031436.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK076507, BY125542
      Consensus CDS
      CCDS17868.1
      UniProtKB/Swiss-Prot
      P28474
      UniProtKB/TrEMBL
      Q6P5I3
      Related
      ENSMUSP00000005964.2, ENSMUST00000005964.6
      Conserved Domains (2) summary
      cd08300
      Location:6373
      alcohol_DH_class_III; class III alcohol dehydrogenases
      COG1062
      Location:6374
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      138437200..138455499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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