Format

Send to:

Choose Destination
    • Showing Current items.

    Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 11532, updated on 2-Oct-2021

    Summary

    Official Symbol
    Adh5provided by MGI
    Official Full Name
    alcohol dehydrogenase 5 (class III), chi polypeptideprovided by MGI
    Primary source
    MGI:MGI:87929
    See related
    Ensembl:ENSMUSG00000028138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adh; Adh-; Adh3; Adh-5; GSNOR
    Expression
    Ubiquitous expression in liver E18 (RPKM 86.3), CNS E11.5 (RPKM 59.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adh5 in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138142961..138161260)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138437200..138455499)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (138106128..138118463)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 6 (class V), pseudogene 1 Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553 Neighboring gene microRNA 1956 Neighboring gene eukaryotic translation initiation factor 4E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-(hydroxymethyl)glutathione dehydrogenase NAD activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables S-(hydroxymethyl)glutathione dehydrogenase NADP activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables S-(hydroxymethyl)glutathione dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables S-(hydroxymethyl)glutathione dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alcohol dehydrogenase activity, zinc-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables formaldehyde dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alcohol dehydrogenase class-3
    Names
    ADH-B2
    FALDH
    FDH
    GSH-FDH
    S-(hydroxymethyl)glutathione dehydrogenase
    S-nitrosoglutathione reductase
    alcohol dehydrogenase 2
    alcohol dehydrogenase B2
    alcohol dehydrogenase class-III
    glutathione-dependent formaldehyde dehydrogenase
    NP_001275507.1
    NP_031436.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288578.1NP_001275507.1  alcohol dehydrogenase class-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, which results in translation intiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK076507, CF172597
      UniProtKB/Swiss-Prot
      P28474
      Conserved Domains (1) summary
      cl16912
      Location:1251
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    2. NM_007410.3NP_031436.2  alcohol dehydrogenase class-3 isoform 1

      See identical proteins and their annotated locations for NP_031436.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK076507, BY125542
      Consensus CDS
      CCDS17868.1
      UniProtKB/Swiss-Prot
      P28474
      UniProtKB/TrEMBL
      Q6P5I3
      Related
      ENSMUSP00000005964.3, ENSMUST00000005964.7
      Conserved Domains (2) summary
      cd08300
      Location:6373
      alcohol_DH_class_III; class III alcohol dehydrogenases
      COG1062
      Location:6374
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      138142961..138161260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center