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    RAB42 RAB42, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 115273, updated on 5-Mar-2024

    Summary

    Official Symbol
    RAB42provided by HGNC
    Official Full Name
    RAB42, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:28702
    See related
    Ensembl:ENSG00000188060 AllianceGenome:HGNC:28702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lymph node (RPKM 2.8), placenta (RPKM 2.4) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RAB42 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28592265..28596666)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28434229..28438630)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28918777..28923178)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28907091-28907876 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28907877-28908662 Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA, H/ACA box 44 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28919769-28920505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28925585-28926166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28928951-28929451 Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene Sharpr-MPRA regulatory region 12118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28971631-28972130 Neighboring gene TAF12 divergent transcript Neighboring gene RNA, U11 small nuclear

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC45806

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-42
    Names
    RAB42, member RAS homolog family
    putative Ras-related protein Rab-42

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193532.3NP_001180461.1  ras-related protein Rab-42 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL513497
      Consensus CDS
      CCDS85943.1
      UniProtKB/Swiss-Prot
      A0A1W2PQ57, B2R5G2, Q8N4Z0
      Related
      ENSP00000491546.1, ENST00000465518.3
      Conserved Domains (1) summary
      cl21455
      Location:8196
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001385188.1NP_001372117.1  ras-related protein Rab-42 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL513497
      Conserved Domains (1) summary
      cl38936
      Location:886
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_152304.3NP_689517.1  ras-related protein Rab-42 isoform 2

      See identical proteins and their annotated locations for NP_689517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL513497, BC033175, BX110464
      Consensus CDS
      CCDS325.1
      UniProtKB/Swiss-Prot
      Q8N4Z0
      Related
      ENSP00000362932.3, ENST00000373826.3
      Conserved Domains (1) summary
      cl21455
      Location:583
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      28592265..28596666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443959.1XP_047299915.1  ras-related protein Rab-42 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      28434229..28438630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334145.1XP_054190120.1  ras-related protein Rab-42 isoform X1