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    ATG4A autophagy related 4A cysteine peptidase [ Homo sapiens (human) ]

    Gene ID: 115201, updated on 24-Nov-2021

    Summary

    Official Symbol
    ATG4Aprovided by HGNC
    Official Full Name
    autophagy related 4A cysteine peptidaseprovided by HGNC
    Primary source
    HGNC:HGNC:16489
    See related
    Ensembl:ENSG00000101844 MIM:300663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APG4A; AUTL2
    Summary
    Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.4), colon (RPKM 5.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See ATG4A in Genome Data Viewer
    Location:
    Xq22.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (108091778..108154671)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (107335008..107397901)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 1 Neighboring gene proteasome 26S subunit, non-ATPase 10 Neighboring gene collagen type IV alpha 6 chain Neighboring gene collagen type IV alpha 5 chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif binds more strongly to autophagy-related protein 4 (ATG4)-cleaved form I (LC3-I) than to ATG4-cleaved form II (LC3-II) in an A3G-independent manner PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cysteine protease ATG4A
    Names
    APG4 autophagy 4 homolog A
    ATG4 autophagy related 4 homolog A
    AUT-like 2, cysteine endopeptidase
    autophagin 2
    autophagy-related cysteine endopeptidase 2
    autophagy-related protein 4 homolog A
    hAPG4A
    NP_001308216.1
    NP_001308217.1
    NP_001308218.1
    NP_001308219.1
    NP_443168.2
    NP_840054.1
    NP_840055.1
    XP_011529144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321287.2NP_001308216.1  cysteine protease ATG4A isoform c

      Status: REVIEWED

      Source sequence(s)
      AL031177
      UniProtKB/Swiss-Prot
      Q8WYN0
      Conserved Domains (1) summary
      pfam03416
      Location:1258
      Peptidase_C54; Peptidase family C54
    2. NM_001321288.2NP_001308217.1  cysteine protease ATG4A isoform c

      Status: REVIEWED

      Source sequence(s)
      AL031177
      UniProtKB/Swiss-Prot
      Q8WYN0
      Conserved Domains (1) summary
      pfam03416
      Location:1258
      Peptidase_C54; Peptidase family C54
    3. NM_001321289.2NP_001308218.1  cysteine protease ATG4A isoform d

      Status: REVIEWED

      Source sequence(s)
      AA648264, AK293533, AL031177, BC041862, BC061696
      UniProtKB/Swiss-Prot
      Q8WYN0
      UniProtKB/TrEMBL
      B4DEA4
      Conserved Domains (1) summary
      pfam03416
      Location:1196
      Peptidase_C54; Peptidase family C54
    4. NM_001321290.2NP_001308219.1  cysteine protease ATG4A isoform e

      Status: REVIEWED

      Source sequence(s)
      AL031177
      Conserved Domains (1) summary
      pfam03416
      Location:1163
      Peptidase_C54; Peptidase family C54
    5. NM_052936.5NP_443168.2  cysteine protease ATG4A isoform a

      See identical proteins and their annotated locations for NP_443168.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (a).
      Source sequence(s)
      AA648264, BC041862, BC061696
      Consensus CDS
      CCDS14538.1
      UniProtKB/Swiss-Prot
      Q8WYN0
      Related
      ENSP00000361306.3, ENST00000372232.8
      Conserved Domains (1) summary
      pfam03416
      Location:42335
      Peptidase_C54; Peptidase family C54
    6. NM_178270.4NP_840054.1  cysteine protease ATG4A isoform b

      See identical proteins and their annotated locations for NP_840054.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AA648264, AJ320509, BC041862, BC061696
      Consensus CDS
      CCDS14539.1
      UniProtKB/Swiss-Prot
      Q8WYN0
      Related
      ENSP00000298131.5, ENST00000345734.7
      Conserved Domains (1) summary
      pfam03416
      Location:43273
      Peptidase_C54; Peptidase family C54
    7. NM_178271.3NP_840055.1  cysteine protease ATG4A isoform c

      Status: REVIEWED

      Source sequence(s)
      AA648264, BC041862, BM541631
      UniProtKB/Swiss-Prot
      Q8WYN0
      Conserved Domains (1) summary
      pfam03416
      Location:1258
      Peptidase_C54; Peptidase family C54

    RNA

    1. NR_135608.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031177
      Related
      ENST00000343524.9

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      108091778..108154671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530842.1XP_011529144.1  cysteine protease ATG4A isoform X1

      See identical proteins and their annotated locations for XP_011529144.1

      UniProtKB/Swiss-Prot
      Q8WYN0
      Conserved Domains (1) summary
      pfam03416
      Location:1258
      Peptidase_C54; Peptidase family C54
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