Format

Send to:

Choose Destination
    • Showing Current items.

    Add1 adducin 1 (alpha) [ Mus musculus (house mouse) ]

    Gene ID: 11518, updated on 31-Jan-2019

    Summary

    Official Symbol
    Add1provided by MGI
    Official Full Name
    adducin 1 (alpha)provided by MGI
    Primary source
    MGI:MGI:87918
    See related
    Ensembl:ENSMUSG00000029106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI256389
    Expression
    Ubiquitous expression in colon adult (RPKM 54.1), cortex adult (RPKM 53.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Add1 in Genome Data Viewer
    Location:
    5 B2; 5 17.9 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (34573714..34632305)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (34916363..34974954)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene TNFAIP3 interacting protein 2 Neighboring gene SH3-domain binding protein 2 Neighboring gene microRNA 7036b Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene NOP14 nucleolar protein Neighboring gene predicted gene 15522

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    spectrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spectrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    barbed-end actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell volume homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemoglobin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of establishment of endothelial barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    F-actin capping protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell adherens junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    alpha-adducin
    Names
    erythrocyte adducin subunit alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024458.4NP_001019629.2  alpha-adducin isoform 1

      See identical proteins and their annotated locations for NP_001019629.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC115695, AF096839, AF189771, AK054558, CD349465, CF531553
      Consensus CDS
      CCDS19216.1
      UniProtKB/Swiss-Prot
      Q9QYC0
      Related
      ENSMUSP00000109979.2, ENSMUST00000114340.8
      Conserved Domains (2) summary
      pfam15310
      Location:595701
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    2. NM_001102444.2NP_001095914.1  alpha-adducin isoform 3

      See identical proteins and their annotated locations for NP_001095914.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the end of an exon and has an alternate exon compared to variant 1 that contains an in-frame stop codon. The resulting isoform (3) contains an internal 31 aa segment not found in isoform 1, but it is still shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC115695, AF096839, AK054558, CF531553
      Consensus CDS
      CCDS51471.1
      UniProtKB/Swiss-Prot
      Q9QYC0
      UniProtKB/TrEMBL
      F8WGR0
      Related
      ENSMUSP00000001108.4, ENSMUST00000001108.10
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    3. NM_001331080.1NP_001318009.1  alpha-adducin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      Consensus CDS
      CCDS19216.1
      UniProtKB/Swiss-Prot
      Q9QYC0
      Conserved Domains (2) summary
      pfam15310
      Location:595701
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    4. NM_001331081.1NP_001318010.1  alpha-adducin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115695
    5. NM_001331082.1NP_001318011.1  alpha-adducin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115695
    6. NM_001331083.1NP_001318012.1  alpha-adducin isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC115695
    7. NM_001331084.1NP_001318013.1  alpha-adducin isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC115695
    8. NM_001331085.1NP_001318014.1  alpha-adducin isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC115695
    9. NM_001331086.1NP_001318015.1  alpha-adducin isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC115695
    10. NM_001331087.1NP_001318016.1  alpha-adducin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115695
      UniProtKB/Swiss-Prot
      Q9QYC0
    11. NM_013457.4NP_038485.1  alpha-adducin isoform 2

      See identical proteins and their annotated locations for NP_038485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon compared to variant 1 that contains an in-frame stop codon. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC115695, AF096839, AK054558, CD349465, CF531553
      Consensus CDS
      CCDS39069.1
      UniProtKB/Swiss-Prot
      Q9QYC0
      Related
      ENSMUSP00000109977.2, ENSMUST00000114338.8
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      34573714..34632305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503669.3XP_006503732.1  alpha-adducin isoform X1

      See identical proteins and their annotated locations for XP_006503732.1

      Conserved Domains (2) summary
      pfam15310
      Location:655761
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    2. XM_017320615.1XP_017176104.1  alpha-adducin isoform X15

      UniProtKB/Swiss-Prot
      Q9QYC0
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    3. XM_006503671.3XP_006503734.1  alpha-adducin isoform X3

      Conserved Domains (2) summary
      pfam15310
      Location:626732
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    4. XM_006503673.3XP_006503736.1  alpha-adducin isoform X6

      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    5. XM_006503675.3XP_006503738.1  alpha-adducin isoform X8

      See identical proteins and their annotated locations for XP_006503738.1

      Related
      ENSMUSP00000109974.1, ENSMUST00000114335.7
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    6. XM_006503668.3XP_006503731.1  alpha-adducin isoform X1

      Conserved Domains (2) summary
      pfam15310
      Location:655761
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    7. XM_006503678.3XP_006503741.1  alpha-adducin isoform X11

      See identical proteins and their annotated locations for XP_006503741.1

      UniProtKB/TrEMBL
      F8WHZ9
      Related
      ENSMUSP00000052266.6, ENSMUST00000052836.13
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    8. XM_006503670.3XP_006503733.1  alpha-adducin isoform X2

      Conserved Domains (2) summary
      pfam15310
      Location:639745
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    9. XM_006503672.3XP_006503735.1  alpha-adducin isoform X4

      Conserved Domains (2) summary
      pfam15310
      Location:624730
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    10. XM_017320614.1XP_017176103.1  alpha-adducin isoform X13

    11. XM_017320616.1XP_017176105.1  alpha-adducin isoform X16

      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    12. XM_017320617.1XP_017176106.1  alpha-adducin isoform X17

      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    13. XM_006503677.2XP_006503740.1  alpha-adducin isoform X10

      See identical proteins and their annotated locations for XP_006503740.1

      UniProtKB/TrEMBL
      F8WGR0
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    14. XM_006503674.2XP_006503737.1  alpha-adducin isoform X7

      See identical proteins and their annotated locations for XP_006503737.1

      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    15. XM_006503676.2XP_006503739.1  alpha-adducin isoform X9

      See identical proteins and their annotated locations for XP_006503739.1

      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    16. XM_006503679.2XP_006503742.1  alpha-adducin isoform X12

      See identical proteins and their annotated locations for XP_006503742.1

      UniProtKB/TrEMBL
      F8WHZ9
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    17. XM_006503680.2XP_006503743.1  alpha-adducin isoform X14

      UniProtKB/TrEMBL
      E9Q1K3
      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    18. XM_006503681.2XP_006503744.1  alpha-adducin isoform X18

      Conserved Domains (1) summary
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    19. XM_017320613.1XP_017176102.1  alpha-adducin isoform X5

      Conserved Domains (2) summary
      pfam15310
      Location:595701
      VAD1-2; Vitamin A-deficiency (VAD) rat model signalling
      cl00214
      Location:145391
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    Support Center