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    Ddhd1 DDHD domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 114874, updated on 9-Sep-2018

    Summary

    Official Symbol
    Ddhd1provided by MGI
    Official Full Name
    DDHD domain containing 1provided by MGI
    Primary source
    MGI:MGI:2150302
    See related
    Ensembl:ENSMUSG00000037697 Vega:OTTMUSG00000023929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mir5131; PA-PLA1
    Expression
    Ubiquitous expression in testis adult (RPKM 28.8), frontal lobe adult (RPKM 12.0) and 27 other tissues See more
    Orthologs

    Genomic context

    See Ddhd1 in Genome Data Viewer
    Location:
    14; 14 C1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (45593171..45658143, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (46212849..46277818, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930527F14 gene Neighboring gene predicted pseudogene 5206 Neighboring gene predicted gene, 41145 Neighboring gene microRNA 5131 Neighboring gene predicted gene, 34360 Neighboring gene 60S ribosomal protein L9 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA1705, 4921528E07Rik, 9630061G18Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phospholipase DDHD1
    Names
    DDHD domain-containing protein 1
    phosphatidic acid-preferring phospholipase A1 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039106.3NP_001034195.2  phospholipase DDHD1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two in-frame exons in the coding region, compared to variant 3. The encoded isoform (1) is shorter, compared to isoform 3.
      Source sequence(s)
      AC107711, AK036369, AK048690, BC043475
      Consensus CDS
      CCDS26978.1
      UniProtKB/Swiss-Prot
      Q80YA3
      UniProtKB/TrEMBL
      F8WHP5
      Related
      ENSMUSP00000050088.6, OTTMUSP00000028840, ENSMUST00000051310.12, OTTMUST00000059304
      Conserved Domains (1) summary
      pfam02862
      Location:598841
      DDHD; DDHD domain
    2. NM_001042719.2NP_001036184.1  phospholipase DDHD1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC107711, AK036369, AK048690, BC043475
      Consensus CDS
      CCDS36895.1
      UniProtKB/Swiss-Prot
      Q80YA3
      UniProtKB/TrEMBL
      F8WIJ5
      Related
      ENSMUSP00000084577.5, OTTMUSP00000028395, ENSMUST00000087320.12, OTTMUST00000058571
      Conserved Domains (1) summary
      pfam02862
      Location:632903
      DDHD; DDHD domain
    3. NM_001284399.1NP_001271328.1  phospholipase DDHD1 isoform 4

      See identical proteins and their annotated locations for NP_001271328.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 3. The encoded isoform (4) has a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AC107711, AK036369, AK048690, BC043475, CK619141
      UniProtKB/Swiss-Prot
      Q80YA3
      Conserved Domains (1) summary
      pfam02862
      Location:261532
      DDHD; DDHD domain
    4. NM_176845.5NP_789815.3  phospholipase DDHD1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 3. The encoded isoform (2) is shorter, compared to isoform 3.
      Source sequence(s)
      AC107711, AK036369, AK048690, BC043475
      Consensus CDS
      CCDS36894.1
      UniProtKB/Swiss-Prot
      Q80YA3
      UniProtKB/TrEMBL
      E9QQ38
      Related
      ENSMUSP00000107459.2, OTTMUSP00000028839, ENSMUST00000111828.3, OTTMUST00000059303
      Conserved Domains (1) summary
      pfam02862
      Location:598869
      DDHD; DDHD domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      45593171..45658143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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