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    PGLYRP2 peptidoglycan recognition protein 2 [ Homo sapiens (human) ]

    Gene ID: 114770, updated on 5-Mar-2024

    Summary

    Official Symbol
    PGLYRP2provided by HGNC
    Official Full Name
    peptidoglycan recognition protein 2provided by HGNC
    Primary source
    HGNC:HGNC:30013
    See related
    Ensembl:ENSG00000161031 MIM:608199; AllianceGenome:HGNC:30013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
    Summary
    This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
    Expression
    Restricted expression toward liver (RPKM 52.9) See more
    Orthologs
    NEW
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    Genomic context

    See PGLYRP2 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15468645..15479501, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15593641..15604523, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15579456..15590312, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WIZ zinc finger Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14185 Neighboring gene microRNA 1470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14188 Neighboring gene RAS protein activator like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15618980-15619480 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 22 Neighboring gene MPRA-validated peak3387 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14191 Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10285

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables N-acetylmuramoyl-L-alanine amidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidoglycan immune receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidoglycan immune receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    N-acetylmuramoyl-L-alanine amidase
    Names
    peptidoglycan recognition protein L
    peptidoglycan recognition protein long
    NP_001350475.1
    NP_443122.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363546.1NP_001350475.1  N-acetylmuramoyl-L-alanine amidase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK055882, AY358156, BC144238
      Consensus CDS
      CCDS86718.1
      Related
      ENSP00000292609.3, ENST00000292609.8
      Conserved Domains (1) summary
      smart00701
      Location:380525
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
    2. NM_052890.4NP_443122.3  N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_443122.3

      Status: VALIDATED

      Source sequence(s)
      AF384856, DB041324
      Consensus CDS
      CCDS12330.2
      UniProtKB/Swiss-Prot
      A8K050, A8K8C7, B2RMZ2, B7ZM33, Q68CK1, Q96N74, Q96PD5, Q9UC60
      Related
      ENSP00000345968.4, ENST00000340880.5
      Conserved Domains (1) summary
      smart00701
      Location:380525
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15468645..15479501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      15593641..15604523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)