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    CARD16 caspase recruitment domain family member 16 [ Homo sapiens (human) ]

    Gene ID: 114769, updated on 7-Jul-2024

    Summary

    Official Symbol
    CARD16provided by HGNC
    Official Full Name
    caspase recruitment domain family member 16provided by HGNC
    Primary source
    HGNC:HGNC:33701
    See related
    Ensembl:ENSG00000204397 MIM:615680; AllianceGenome:HGNC:33701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COP; COP1; PSEUDO-ICE; LLID-114769
    Summary
    Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen (RPKM 14.0), appendix (RPKM 12.0) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CARD16 in Genome Data Viewer
    Location:
    11q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (105041563..105045335, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (105045653..105049425, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (104912290..104916062, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11455 Neighboring gene caspase 5 Neighboring gene uncharacterized LOC124902742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5460 Neighboring gene caspase 1 Neighboring gene uncharacterized LOC107984381 Neighboring gene caspase 1 pseudogene 2 Neighboring gene caspase recruitment domain family member 17, pseudogene Neighboring gene caspase 1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of caspase recruitment domain family, member 16 (CARD16; COP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CARD domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables caspase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables caspase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AIM2 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of IPAF inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NLRP3 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protease inhibitor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 16
    Names
    CARD only domain-containing protein 1
    CARD only protein
    CARD-only protein 1
    caspase recruitment domain-only protein 1
    caspase-1 dominant-negative inhibitor pseudo-ICE
    caspase-1 inhibitor COP
    pseudo interleukin-1 beta converting enzyme
    pseudo interleukin-1beta converting enzyme
    pseudo-IL1B-converting enzyme

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394580.1NP_001381509.1  caspase recruitment domain-containing protein 16 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AP001153
      Conserved Domains (1) summary
      cd08325
      Location:171
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
    2. NM_052889.4NP_443121.1  caspase recruitment domain-containing protein 16 isoform 2

      See identical proteins and their annotated locations for NP_443121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AP001153
      Consensus CDS
      CCDS41705.1
      UniProtKB/TrEMBL
      Q5FBZ0
      Related
      ENSP00000509408.1, ENST00000673097.2
      Conserved Domains (1) summary
      cd08325
      Location:587
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      105041563..105045335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      105045653..105049425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_024408.1: Suppressed sequence

      Description
      NG_024408.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    2. NM_001017534.2: Suppressed sequence

      Description
      NM_001017534.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.