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    Rasa2 RAS p21 protein activator 2 [ Mus musculus (house mouse) ]

    Gene ID: 114713, updated on 9-Sep-2018

    Summary

    Official Symbol
    Rasa2provided by MGI
    Official Full Name
    RAS p21 protein activator 2provided by MGI
    Primary source
    MGI:MGI:2149960
    See related
    Ensembl:ENSMUSG00000032413 Vega:OTTMUSG00000020654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAP1m; AA517451; AU023900; 5430433H21Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 4.5), limb E14.5 (RPKM 2.3) and 26 other tissues See more
    Orthologs

    Genomic context

    See Rasa2 in Genome Data Viewer
    Location:
    9; 9 E3.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (96539300..96631625, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (96439719..96531922, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 28729 Neighboring gene predicted gene, 46125 Neighboring gene ubiquitin domain containing 2 pseudogene Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene RIKEN cDNA E030011O05 gene Neighboring gene RIKEN cDNA C430002N11 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053268.2NP_444498.2  ras GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_444498.2

      Status: VALIDATED

      Source sequence(s)
      AC144935, AC161257
      Consensus CDS
      CCDS23416.1
      UniProtKB/Swiss-Prot
      P58069
      Related
      ENSMUSP00000034984.6, OTTMUSP00000022558, ENSMUST00000034984.7, OTTMUST00000048922
      Conserved Domains (7) summary
      smart00107
      Location:706741
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:171313
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:38158
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      smart00323
      Location:300640
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13370
      Location:589721
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      pfam00169
      Location:606704
      PH; PH domain
      cl02569
      Location:322592
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      96539300..96631625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510775.2XP_006510838.1  ras GTPase-activating protein 2 isoform X1

      Conserved Domains (7) summary
      smart00107
      Location:743778
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:208350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      smart00323
      Location:337677
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13370
      Location:626758
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      pfam00169
      Location:643741
      PH; PH domain
      cl02569
      Location:359629
      RasGAP; Ras GTPase Activating Domain
    2. XM_006510776.3XP_006510839.1  ras GTPase-activating protein 2 isoform X2

      Conserved Domains (7) summary
      smart00107
      Location:649684
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      smart00323
      Location:243583
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13370
      Location:532664
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      pfam00169
      Location:549647
      PH; PH domain
      cl02569
      Location:265535
      RasGAP; Ras GTPase Activating Domain
      cl14603
      Location:1101
      C2; C2 domain
    3. XM_017313108.1XP_017168597.1  ras GTPase-activating protein 2 isoform X4

    4. XM_006510777.3XP_006510840.1  ras GTPase-activating protein 2 isoform X3

      Conserved Domains (4) summary
      cd04010
      Location:208350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      smart00323
      Location:337586
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl02569
      Location:359594
      RasGAP; Ras GTPase Activating Domain
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