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    Rasa2 RAS p21 protein activator 2 [ Mus musculus (house mouse) ]

    Gene ID: 114713, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rasa2provided by MGI
    Official Full Name
    RAS p21 protein activator 2provided by MGI
    Primary source
    MGI:MGI:2149960
    See related
    Ensembl:ENSMUSG00000032413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAP; GAP1m; AA517451; AU023900; 5430433H21Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 4.5), limb E14.5 (RPKM 2.3) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rasa2 in Genome Data Viewer
    Location:
    9; 9 E3.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96421353..96513665, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (96539300..96631612, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (96439719..96531922, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28729 Neighboring gene ubiquitin domain containing 2 pseudogene Neighboring gene protein transport protein Sec61 subunit gamma-like Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene RIKEN cDNA E030011O05 gene Neighboring gene RIKEN cDNA C430002N11 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053268.2NP_444498.2  ras GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_444498.2

      Status: VALIDATED

      Source sequence(s)
      AC144935, AC161257
      Consensus CDS
      CCDS23416.1
      UniProtKB/Swiss-Prot
      P58069
      Related
      ENSMUSP00000034984.7, ENSMUST00000034984.8
      Conserved Domains (7) summary
      smart00107
      Location:706741
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:171313
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:38158
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      smart00323
      Location:300640
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13370
      Location:589721
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      pfam00169
      Location:606704
      PH; PH domain
      cl02569
      Location:322592
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      96421353..96513665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510776.5XP_006510839.1  ras GTPase-activating protein 2 isoform X2

      Conserved Domains (5) summary
      smart00107
      Location:649684
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd13370
      Location:532664
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      cl02569
      Location:265535
      RasGAP; Ras GTPase Activating Domain
      cl14603
      Location:1101
      C2; C2 domain
    2. XM_036154565.1XP_036010458.1  ras GTPase-activating protein 2 isoform X6

      Conserved Domains (3) summary
      smart00107
      Location:299334
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd13370
      Location:182314
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      cl02569
      Location:1185
      RasGAP; Ras GTPase Activating Domain
    3. XM_006510775.4XP_006510838.1  ras GTPase-activating protein 2 isoform X1

      Conserved Domains (5) summary
      smart00107
      Location:743778
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:208350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd13370
      Location:626758
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      cl02569
      Location:359629
      RasGAP; Ras GTPase Activating Domain
    4. XM_036154564.1XP_036010457.1  ras GTPase-activating protein 2 isoform X3

      Conserved Domains (3) summary
      cd04010
      Location:208350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cl02569
      Location:359620
      RasGAP; Ras GTPase Activating Domain
    5. XM_017313108.2XP_017168597.1  ras GTPase-activating protein 2 isoform X5

      Conserved Domains (3) summary
      cd04010
      Location:171313
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:38158
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cl02569
      Location:322557
      RasGAP; Ras GTPase Activating Domain
    6. XM_006510777.5XP_006510840.1  ras GTPase-activating protein 2 isoform X4

      Conserved Domains (3) summary
      cd04010
      Location:208350
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:82195
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cl02569
      Location:359594
      RasGAP; Ras GTPase Activating Domain

    RNA

    1. XR_004935308.1 RNA Sequence

    2. XR_004935307.1 RNA Sequence

    3. XR_004935304.1 RNA Sequence

    4. XR_004935305.1 RNA Sequence

    5. XR_004935306.1 RNA Sequence

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