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    Brdt bromodomain, testis-specific [ Mus musculus (house mouse) ]

    Gene ID: 114642, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brdtprovided by MGI
    Official Full Name
    bromodomain, testis-specificprovided by MGI
    Primary source
    MGI:MGI:1891374
    See related
    Ensembl:ENSMUSG00000029279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brd6; Fsrg3; 7420412D09Rik
    Summary
    The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis adult (RPKM 12.3), cortex adult (RPKM 1.6) and 6 other tissues See more
    Orthologs

    Genomic context

    See Brdt in Genome Data Viewer
    Location:
    5; 5 E5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (107331084..107387061)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (107760213..107816077)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42146 Neighboring gene transforming growth factor, beta receptor III Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene predicted gene 17202 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene epoxide hydrolase 4 Neighboring gene lysophosphatidylcholine acyltransferase 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    lysine-acetylated histone binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    histone displacement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription involved in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bromodomain testis-specific protein
    Names
    RING3-like protein
    bromodomain-containing female sterile homeotic-like protein
    female sterile homeotic-related gene 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079873.1NP_001073342.1  bromodomain testis-specific protein isoform B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform B) that lacks the 3' bromodomain and ET domain, compared to isoform A.
      Source sequence(s)
      AK077137
      Consensus CDS
      CCDS39197.1
      UniProtKB/Swiss-Prot
      Q91Y44
      Related
      ENSMUSP00000108297.3, ENSMUST00000112677.9
      Conserved Domains (2) summary
      cd05497
      Location:26132
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cl02556
      Location:271322
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    2. NM_054054.2NP_473395.2  bromodomain testis-specific protein isoform A

      See identical proteins and their annotated locations for NP_473395.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AF358660, AK039465, AK078663, BY724250, BY726053
      Consensus CDS
      CCDS19500.1
      UniProtKB/Swiss-Prot
      Q91Y44
      UniProtKB/TrEMBL
      Q8BNZ8
      Related
      ENSMUSP00000031215.8, ENSMUST00000031215.14
      Conserved Domains (4) summary
      cd05497
      Location:26132
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:271372
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:505569
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:914956
      BRD4_CDT; C-terminal domain of bromodomain protein 4

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      107331084..107387061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249399.2XP_011247701.1  bromodomain testis-specific protein isoform X4

      Conserved Domains (3) summary
      cd05497
      Location:26132
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:271372
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:505569
      BET; Bromodomain extra-terminal - transcription regulation
    2. XM_017320607.1XP_017176096.1  bromodomain testis-specific protein isoform X2

    3. XM_011249398.2XP_011247700.1  bromodomain testis-specific protein isoform X1

      See identical proteins and their annotated locations for XP_011247700.1

      Conserved Domains (4) summary
      cd05497
      Location:26132
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:271372
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:505569
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:919961
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    4. XM_006534728.3XP_006534791.1  bromodomain testis-specific protein isoform X1

      See identical proteins and their annotated locations for XP_006534791.1

      Conserved Domains (4) summary
      cd05497
      Location:26132
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:271372
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:505569
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:919961
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    5. XM_017320608.1XP_017176097.1  bromodomain testis-specific protein isoform X3

    6. XM_006534730.3XP_006534793.1  bromodomain testis-specific protein isoform X1

      See identical proteins and their annotated locations for XP_006534793.1

      Conserved Domains (4) summary
      cd05497
      Location:26132
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:271372
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:505569
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:919961
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    7. XM_006534729.3XP_006534792.1  bromodomain testis-specific protein isoform X1

      See identical proteins and their annotated locations for XP_006534792.1

      Conserved Domains (4) summary
      cd05497
      Location:26132
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:271372
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:505569
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:919961
      BRD4_CDT; C-terminal domain of bromodomain protein 4

    RNA

    1. XR_001784595.1 RNA Sequence

    2. XR_001784594.1 RNA Sequence

    3. XR_001784596.1 RNA Sequence

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