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    Tle6 transducin-like enhancer of split 6 [ Mus musculus (house mouse) ]

    Gene ID: 114606, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tle6provided by MGI
    Official Full Name
    transducin-like enhancer of split 6provided by MGI
    Primary source
    MGI:MGI:2149593
    See related
    Ensembl:ENSMUSG00000034758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grg; Grg6; 1810057E06Rik
    Expression
    Broad expression in ovary adult (RPKM 24.8), adrenal adult (RPKM 10.1) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tle6 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81426738..81437021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81590904..81601185, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (81053650..81063645, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene predicted gene, 31936 Neighboring gene transducin-like enhancer of split 2 Neighboring gene zinc finger protein pseudogene Neighboring gene sirtuin 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of subcortical maternal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of subcortical maternal complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transducin-like enhancer protein 6
    Names
    Groucho-related protein 6
    transducin-like enhancer of split 6, homolog of Drosophila E(spl)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346695.1NP_001333624.1  transducin-like enhancer protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153919
      Consensus CDS
      CCDS83737.1
      UniProtKB/TrEMBL
      D3Z5E1
      Related
      ENSMUSP00000117287.2, ENSMUST00000142948.8
      Conserved Domains (2) summary
      sd00039
      Location:289331
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:277563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001359134.1NP_001346063.1  transducin-like enhancer protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BC048832
      Related
      ENSMUST00000128278.8
      Conserved Domains (2) summary
      sd00039
      Location:226268
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:214500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001359135.1NP_001346064.1  transducin-like enhancer protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BC048832, BY236020
      Conserved Domains (2) summary
      sd00039
      Location:226268
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:214500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_053254.2NP_444484.1  transducin-like enhancer protein 6 isoform 1

      See identical proteins and their annotated locations for NP_444484.1

      Status: VALIDATED

      Source sequence(s)
      AC153919
      Consensus CDS
      CCDS24064.1
      UniProtKB/Swiss-Prot
      Q9WVB3
      Related
      ENSMUSP00000071905.3, ENSMUST00000072020.9
      Conserved Domains (2) summary
      sd00039
      Location:299341
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:287573
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81426738..81437021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513083.4XP_006513146.1  transducin-like enhancer protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006513146.1

      Conserved Domains (2) summary
      sd00039
      Location:299369
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:287601
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_036155507.1XP_036011400.1  transducin-like enhancer protein 6 isoform X4

      Conserved Domains (2) summary
      sd00039
      Location:289331
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:277563
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_036155506.1XP_036011399.1  transducin-like enhancer protein 6 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:299341
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:287573
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_006513085.5XP_006513148.1  transducin-like enhancer protein 6 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:289359
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:277591
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_006513081.5XP_006513144.1  transducin-like enhancer protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006513144.1

      Conserved Domains (2) summary
      sd00039
      Location:299369
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:287601
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_017313766.3XP_017169255.1  transducin-like enhancer protein 6 isoform X5

      Conserved Domains (2) summary
      COG2319
      Location:198560
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:259329
      7WD40; WD40 repeat [structural motif]
    7. XM_036155512.1XP_036011405.1  transducin-like enhancer protein 6 isoform X8

      Conserved Domains (2) summary
      sd00039
      Location:216258
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:204490
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. XM_036155511.1XP_036011404.1  transducin-like enhancer protein 6 isoform X9

      Conserved Domains (2) summary
      sd00039
      Location:226268
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:214500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    9. XM_036155513.1XP_036011406.1  transducin-like enhancer protein 6 isoform X8

      Conserved Domains (2) summary
      sd00039
      Location:216258
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:204490
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. XM_036155508.1XP_036011401.1  transducin-like enhancer protein 6 isoform X6

      Conserved Domains (2) summary
      COG2319
      Location:165527
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:226296
      7WD40; WD40 repeat [structural motif]
    11. XM_036155509.1XP_036011402.1  transducin-like enhancer protein 6 isoform X7

      Conserved Domains (2) summary
      COG2319
      Location:155517
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:216286
      7WD40; WD40 repeat [structural motif]
    12. XM_006513088.4XP_006513151.1  transducin-like enhancer protein 6 isoform X6

      See identical proteins and their annotated locations for XP_006513151.1

      Conserved Domains (2) summary
      COG2319
      Location:165527
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:226296
      7WD40; WD40 repeat [structural motif]
    13. XM_030244827.2XP_030100687.1  transducin-like enhancer protein 6 isoform X6

      Conserved Domains (2) summary
      COG2319
      Location:165527
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:226296
      7WD40; WD40 repeat [structural motif]
    14. XM_030244828.2XP_030100688.1  transducin-like enhancer protein 6 isoform X7

      Conserved Domains (2) summary
      COG2319
      Location:155517
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:216286
      7WD40; WD40 repeat [structural motif]
    15. XM_036155510.1XP_036011403.1  transducin-like enhancer protein 6 isoform X8

      Related
      ENSMUST00000137631.8
      Conserved Domains (2) summary
      sd00039
      Location:216258
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:204490
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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