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    Acox1 acyl-Coenzyme A oxidase 1, palmitoyl [ Mus musculus (house mouse) ]

    Gene ID: 11430, updated on 31-Jan-2019

    Summary

    Official Symbol
    Acox1provided by MGI
    Official Full Name
    acyl-Coenzyme A oxidase 1, palmitoylprovided by MGI
    Primary source
    MGI:MGI:1330812
    See related
    Ensembl:ENSMUSG00000020777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AOX; Acox; Paox; D130055E20Rik
    Summary
    This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Broad expression in liver adult (RPKM 251.9), liver E18 (RPKM 159.5) and 21 other tissues See more
    Orthologs

    Genomic context

    See Acox1 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (116171883..116199045, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (116033202..116060359, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene Fas (TNFRSF6) binding factor 1 Neighboring gene TEN1 telomerase capping complex subunit Neighboring gene cyclin-dependent kinase 3 Neighboring gene envoplakin Neighboring gene predicted gene, 33250

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • D130055E20Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acyl-CoA oxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    palmitoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    palmitoyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid beta-oxidation using acyl-CoA oxidase ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
     
    lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxisomal acyl-coenzyme A oxidase 1
    Names
    palmitoyl-CoA oxidase
    peroxisomal fatty acyl-coenzyme A oxidase
    peroxisomal straight-chain Acyl-CoA oxidase
    NP_001258827.1
    NP_056544.2
    XP_006532065.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271898.1NP_001258827.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 2

      See identical proteins and their annotated locations for NP_001258827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is the same length as isoform 1.
      Source sequence(s)
      AL607108, AL669925, BC056448
      Consensus CDS
      CCDS70354.1
      UniProtKB/Swiss-Prot
      Q9R0H0
      Related
      ENSMUSP00000072717.4, ENSMUST00000072948.10
      Conserved Domains (2) summary
      cd01150
      Location:3638
      AXO; Peroxisomal acyl-CoA oxidase
      PLN02443
      Location:5657
      PLN02443; acyl-coenzyme A oxidase
    2. NM_015729.3NP_056544.2  peroxisomal acyl-coenzyme A oxidase 1 isoform 1

      See identical proteins and their annotated locations for NP_056544.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL607108, BC056448
      Consensus CDS
      CCDS25660.1
      UniProtKB/Swiss-Prot
      Q9R0H0
      Related
      ENSMUSP00000063325.5, ENSMUST00000066587.11
      Conserved Domains (2) summary
      cd01150
      Location:3638
      AXO; Peroxisomal acyl-CoA oxidase
      PLN02443
      Location:5657
      PLN02443; acyl-coenzyme A oxidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      116171883..116199045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532002.3XP_006532065.1  peroxisomal acyl-coenzyme A oxidase 1 isoform X1

      Related
      ENSMUSP00000122185.1, ENSMUST00000148601.1
      Conserved Domains (1) summary
      cd01150
      Location:23570
      AXO; Peroxisomal acyl-CoA oxidase
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