Format

Send to:

Choose Destination
    • Showing Current items.

    Acox1 acyl-Coenzyme A oxidase 1, palmitoyl [ Mus musculus (house mouse) ]

    Gene ID: 11430, updated on 23-Jun-2021

    Summary

    Official Symbol
    Acox1provided by MGI
    Official Full Name
    acyl-Coenzyme A oxidase 1, palmitoylprovided by MGI
    Primary source
    MGI:MGI:1330812
    See related
    Ensembl:ENSMUSG00000020777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; AOX; Acox; Paox; D130055E20Rik
    Summary
    This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Broad expression in liver adult (RPKM 251.9), liver E18 (RPKM 159.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Acox1 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116062709..116089871, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116171883..116199045, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (116033202..116060359, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene Fas (TNFRSF6) binding factor 1 Neighboring gene predicted gene, 26413 Neighboring gene TEN1 telomerase capping complex subunit Neighboring gene cyclin-dependent kinase 3 Neighboring gene envoplakin Neighboring gene predicted gene, 33250

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • D130055E20Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables acyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables acyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyl-CoA oxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    enables palmitoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables palmitoyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid beta-oxidation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in generation of precursor metabolites and energy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in very long-chain fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisomal acyl-coenzyme A oxidase 1
    Names
    palmitoyl-CoA oxidase
    peroxisomal fatty acyl-coenzyme A oxidase
    peroxisomal straight-chain Acyl-CoA oxidase
    NP_001258827.1
    NP_001364450.1
    NP_001364451.1
    NP_056544.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271898.1NP_001258827.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 2

      See identical proteins and their annotated locations for NP_001258827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is the same length as isoform 1.
      Source sequence(s)
      AL607108, AL669925, BC056448
      Consensus CDS
      CCDS70354.1
      UniProtKB/Swiss-Prot
      Q9R0H0
      Related
      ENSMUSP00000072717.5, ENSMUST00000072948.11
      Conserved Domains (1) summary
      cd01150
      Location:3638
      AXO; Peroxisomal acyl-CoA oxidase
    2. NM_001377521.1NP_001364450.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL607108, AL669925
      Related
      ENSMUSP00000122185.2, ENSMUST00000148601.2
      Conserved Domains (1) summary
      cd01150
      Location:23570
      AXO; Peroxisomal acyl-CoA oxidase
    3. NM_001377522.1NP_001364451.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL607108, AL669925
      Conserved Domains (1) summary
      cl09933
      Location:3562
      ACAD; Acyl-CoA dehydrogenase
    4. NM_015729.3NP_056544.2  peroxisomal acyl-coenzyme A oxidase 1 isoform 1

      See identical proteins and their annotated locations for NP_056544.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL607108, BC056448
      Consensus CDS
      CCDS25660.1
      UniProtKB/Swiss-Prot
      Q9R0H0
      Related
      ENSMUSP00000063325.6, ENSMUST00000066587.12
      Conserved Domains (2) summary
      cd01150
      Location:3638
      AXO; Peroxisomal acyl-CoA oxidase
      PLN02443
      Location:5657
      PLN02443; acyl-coenzyme A oxidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116062709..116089871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center