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    Dok4 docking protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 114255, updated on 4-Nov-2018

    Summary

    Official Symbol
    Dok4provided by MGI
    Official Full Name
    docking protein 4provided by MGI
    Primary source
    MGI:MGI:2148865
    See related
    Ensembl:ENSMUSG00000040631 Vega:OTTMUSG00000061707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in colon adult (RPKM 63.0), large intestine adult (RPKM 54.8) and 23 other tissues See more
    Orthologs

    Genomic context

    See Dok4 in Genome Data Viewer
    Location:
    8; 8 C5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (94863828..94876312, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (97387728..97400212, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene cytokine induced apoptosis inhibitor 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene coenzyme Q9 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C Neighboring gene coiled-coil domain containing 102A Neighboring gene adhesion G protein-coupled receptor G5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    docking protein 4
    Names
    downstream of tyrosine kinase 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053246.3NP_444476.1  docking protein 4

      See identical proteins and their annotated locations for NP_444476.1

      Status: VALIDATED

      Source sequence(s)
      AC129606
      Consensus CDS
      CCDS40443.1
      UniProtKB/Swiss-Prot
      Q99KE3
      Related
      ENSMUSP00000043554.7, OTTMUSP00000078072, ENSMUST00000046461.8, OTTMUST00000150575
      Conserved Domains (2) summary
      cd13164
      Location:133235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      94863828..94876312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530579.3XP_006530642.1  docking protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006530642.1

      UniProtKB/Swiss-Prot
      Q99KE3
      Related
      ENSMUSP00000148355.1, OTTMUSP00000078071, ENSMUST00000212810.1, OTTMUST00000150574
      Conserved Domains (2) summary
      cd13164
      Location:133235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
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