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    Acadm acyl-Coenzyme A dehydrogenase, medium chain [ Mus musculus (house mouse) ]

    Gene ID: 11364, updated on 19-Mar-2019

    Summary

    Official Symbol
    Acadmprovided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase, medium chainprovided by MGI
    Primary source
    MGI:MGI:87867
    See related
    Ensembl:ENSMUSG00000062908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCAD; AU018656
    Summary
    This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in heart adult (RPKM 179.5), liver E18 (RPKM 140.4) and 20 other tissues See more
    Orthologs

    Genomic context

    See Acadm in Genome Data Viewer
    Location:
    3 H3; 3 78.77 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (153922353..153944643, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (153585323..153607396, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene Rab geranylgeranyl transferase, b subunit Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene solute carrier family 44, member 5 Neighboring gene predicted gene, 40185 Neighboring gene predicted gene 3076

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    medium-chain-acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    medium-chain-acyl-CoA dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    medium-chain-acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carnitine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    carnitine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carnitine metabolic process, CoA-linked IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carnitine metabolic process, CoA-linked ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    medium-chain fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    medium-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    organic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    medium-chain specific acyl-CoA dehydrogenase, mitochondrial
    NP_031408.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007382.5NP_031408.1  medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031408.1

      Status: REVIEWED

      Source sequence(s)
      AC087184, AK146444, BB745012, CX232934
      Consensus CDS
      CCDS17924.1
      UniProtKB/Swiss-Prot
      P45952
      Related
      ENSMUSP00000072483.6, ENSMUST00000072697.12
      Conserved Domains (2) summary
      cd01157
      Location:41418
      MCAD; Medium chain acyl-CoA dehydrogenase
      COG1960
      Location:39420
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      153922353..153944643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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