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    Abl2 v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) [ Mus musculus (house mouse) ]

    Gene ID: 11352, updated on 5-Sep-2021

    Summary

    Official Symbol
    Abl2provided by MGI
    Official Full Name
    v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)provided by MGI
    Primary source
    MGI:MGI:87860
    See related
    Ensembl:ENSMUSG00000026596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Arg; Abll; AA536808
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 5.8), whole brain E14.5 (RPKM 3.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Abl2 in Genome Data Viewer
    Location:
    1 G3; 1 67.71 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156386160..156477189)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156558590..156649619)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (158488918..158579750)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene casein kinase 2, alpha 1 polypeptide, pseudogene 3 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene torsin family 3, member A Neighboring gene FAM20B, glycosaminoglycan xylosylkinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC169395

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Bergmann glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within actin filament organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within alpha-beta T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within auditory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebellum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within circulatory system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within exploration behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuroepithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phagocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of interferon-gamma production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-2 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within substrate-dependent cell migration, cell extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synapse maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase ABL2
    Names
    Abelson tyrosine-protein kinase 2
    Abelson-related gene protein
    abelson murine leukemia viral oncogene homolog 2
    tyrosine kinase ARG
    tyrosine-protein kinase ARG
    v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
    NP_001129576.1
    NP_033725.2
    XP_006496676.1
    XP_006496677.1
    XP_006496678.1
    XP_006496679.1
    XP_006496680.1
    XP_006496683.1
    XP_006496684.1
    XP_006496685.1
    XP_011237039.1
    XP_011237040.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136104.1NP_001129576.1  tyrosine-protein kinase ABL2 isoform a

      See identical proteins and their annotated locations for NP_001129576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame segment in the 3' coding region, as compared to variant 2. The resulting isoform (a, also known as 1BLCTS) lacks an internal segment in the C-termius, as compared to isoform b.
      Source sequence(s)
      AC145078, BC137771, CJ171655
      Consensus CDS
      CCDS48404.1
      UniProtKB/TrEMBL
      B2RQ57
      Related
      ENSMUSP00000126181.3, ENSMUST00000166172.9
      Conserved Domains (5) summary
      smart00808
      Location:9591078
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:288539
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    2. NM_009595.3NP_033725.2  tyrosine-protein kinase ABL2 isoform b

      See identical proteins and their annotated locations for NP_033725.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (b, also known as 1BLCTL).
      Source sequence(s)
      AC145078, BC137771, CJ171655
      Consensus CDS
      CCDS15393.1
      UniProtKB/TrEMBL
      B2RQ57, F8VQH0
      Related
      ENSMUSP00000027888.7, ENSMUST00000027888.13
      Conserved Domains (5) summary
      smart00808
      Location:10631182
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      smart00221
      Location:288539
      STYKc; Protein kinase; unclassified specificity
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      156386160..156477189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238737.3XP_011237039.1  tyrosine-protein kinase ABL2 isoform X1

      Conserved Domains (4) summary
      smart00808
      Location:10621181
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    2. XM_011238738.3XP_011237040.1  tyrosine-protein kinase ABL2 isoform X7

      Conserved Domains (4) summary
      smart00808
      Location:9581077
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    3. XM_006496615.4XP_006496678.1  tyrosine-protein kinase ABL2 isoform X4

      Conserved Domains (4) summary
      smart00808
      Location:10421161
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    4. XM_006496616.4XP_006496679.1  tyrosine-protein kinase ABL2 isoform X5

      Conserved Domains (4) summary
      smart00808
      Location:10411160
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    5. XM_006496621.4XP_006496684.1  tyrosine-protein kinase ABL2 isoform X9

      Conserved Domains (4) summary
      smart00808
      Location:9371056
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    6. XM_006496613.5XP_006496676.1  tyrosine-protein kinase ABL2 isoform X2

      Conserved Domains (4) summary
      smart00808
      Location:10481167
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    7. XM_006496614.5XP_006496677.1  tyrosine-protein kinase ABL2 isoform X3

      Conserved Domains (4) summary
      smart00808
      Location:10471166
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    8. XM_006496617.5XP_006496680.1  tyrosine-protein kinase ABL2 isoform X6

      Conserved Domains (4) summary
      smart00808
      Location:10271146
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    9. XM_006496620.5XP_006496683.1  tyrosine-protein kinase ABL2 isoform X8

      Conserved Domains (4) summary
      smart00808
      Location:9431062
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    10. XM_006496622.5XP_006496685.1  tyrosine-protein kinase ABL2 isoform X10

      Conserved Domains (4) summary
      smart00808
      Location:9221041
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
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