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    CTRC chymotrypsin C [ Homo sapiens (human) ]

    Gene ID: 11330, updated on 8-Jul-2021

    Summary

    Official Symbol
    CTRCprovided by HGNC
    Official Full Name
    chymotrypsin Cprovided by HGNC
    Primary source
    HGNC:HGNC:2523
    See related
    Ensembl:ENSG00000162438 MIM:601405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLCR; ELA4
    Summary
    This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward pancreas (RPKM 2413.6) See more
    Orthologs
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    Genomic context

    See CTRC in Genome Data Viewer
    Location:
    1p36.21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (15438442..15449247)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15764939..15775737)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene forkhead associated phosphopeptide binding domain 1 Neighboring gene FHAD1 antisense RNA 1 Neighboring gene uncharacterized LOC101927441 Neighboring gene EF-hand domain family member D2 Neighboring gene uncharacterized LOC105376767 Neighboring gene chymotrypsin like elastase 2A Neighboring gene chymotrypsin like elastase 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cobalamin metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    chymotrypsin-C
    Names
    caldecrin
    elastase 4
    elastase IV
    serum calcium decreasing factor
    NP_009203.2
    XP_011538852.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009253.1 RefSeqGene

      Range
      5001..13216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007272.3NP_009203.2  chymotrypsin-C preproprotein

      See identical proteins and their annotated locations for NP_009203.2

      Status: REVIEWED

      Source sequence(s)
      AL031283, BC015118, S82198
      Consensus CDS
      CCDS156.1
      UniProtKB/Swiss-Prot
      Q99895
      Related
      ENSP00000365116.4, ENST00000375949.5
      Conserved Domains (1) summary
      cd00190
      Location:30265
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      15438442..15449247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540550.1XP_011538852.1  chymotrypsin-C isoform X1

      Conserved Domains (2) summary
      smart00020
      Location:29163
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:30173
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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